Blood Rheology Alterations in Patients with Cardiovascular Diseases

Overview

Journal Rom J Anaesth Intensive Care

Publisher Sciendo

Specialty Anesthesiology

Date 2023 Feb 27

PMID 36844116

Authors

Liana Valeanu

Carmen Ginghina

Serban Bubenek-Turconi

Affiliations

Soon will be listed here.

Abstract

Blood rheology is an important determinant of blood flow but is probably one of the most neglected areas in clinical literature and practice. Blood viscosity changes according to shear rates and depends on cellular and plasma factors. RBCs' aggregability and deformability are the main determinants of local flow characteristics in areas with lower and higher shear rates, but plasma viscosity is the main regulatory factor of flow resistance in the microcirculation. In individuals with altered blood rheology, the mechanical stress to vascular walls induces endothelial injury and vascular remodelling, and promotes atherosclerosis. Increased values of whole blood viscosity and plasma viscosity are correlated with cardiovascular risk factors and adverse cardiovascular events. The long-term effects of physical exercise can produce a hemorheological fitness that protects against cardiovascular diseases.

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References

Brun J, Bouchahda C, Chaze D, Benhaddad A, Micallef J, Mercier J . The paradox of hematocrit in exercise physiology: which is the "normal" range from an hemorheologist's viewpoint?. Clin Hemorheol Microcirc. 2000; 22(4):287-303. View

Tsai A, Friesenecker B, McCarthy M, Sakai H, Intaglietta M . Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model. Am J Physiol. 1998; 275(6):H2170-80. DOI: 10.1152/ajpheart.1998.275.6.H2170. View

Danesh J, Collins R, Peto R, Lowe G . Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies of coronary heart disease. Eur Heart J. 2000; 21(7):515-20. DOI: 10.1053/euhj.1999.1699. View

Lapoumeroulie C, Connes P, El Hoss S, Hierso R, Charlot K, Lemonne N . New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. Br J Haematol. 2018; 185(5):991-994. DOI: 10.1111/bjh.15686. View

Smith W, Lowe G, Lee A, Tunstall-Pedoe H . Rheological determinants of blood pressure in a Scottish adult population. J Hypertens. 1992; 10(5):467-72. DOI: 10.1097/00004872-199205000-00010. View

Carallo C, Irace C, De Franceschi M, Coppoletta F, Tiriolo R, Scicchitano C . The effect of aging on blood and plasma viscosity. An 11.6 years follow-up study. Clin Hemorheol Microcirc. 2011; 47(1):67-74. DOI: 10.3233/CH-2010-1367. View

BARNES A, Locke P, Scudder P, Dormandy T, Dormandy J, Slack J . Is hyperviscosity a treatable component of diabetic microcirculatory disease?. Lancet. 1977; 2(8042):789-91. DOI: 10.1016/s0140-6736(77)90724-3. View

Feher G, Koltai K, Kesmarky G, Szapary L, Juricskay I, Toth K . Hemorheological parameters and aging. Clin Hemorheol Microcirc. 2006; 35(1-2):89-98. View

Kilic-Toprak E, Ardic F, Erken G, Unver-Kocak F, Kucukatay V, Bor-Kucukatay M . Hemorheological responses to progressive resistance exercise training in healthy young males. Med Sci Monit. 2012; 18(6):CR351-60. PMC: 3560717. DOI: 10.12659/msm.882878. View

10.

Cowan A, Cho D, Rosenson R . Importance of blood rheology in the pathophysiology of atherothrombosis. Cardiovasc Drugs Ther. 2012; 26(4):339-48. DOI: 10.1007/s10557-012-6402-4. View

11.

Zannad F, Voisin P, Brunotte F, Bruntz J, Stoltz J, GILGENKRANTZ J . Haemorheological abnormalities in arterial hypertension and their relation to cardiac hypertrophy. J Hypertens. 1988; 6(4):293-7. View

12.

Shasha S, Kamal H, Kristal B, Galetzky G, Roguin N, Shkolnik T . Red cell filterability in cigarette smokers and its relations to cardiac hypertrophy. Atherosclerosis. 1993; 98(1):91-8. DOI: 10.1016/0021-9150(93)90226-k. View

13.

Yalcin O, Meiselman H, Armstrong J, Baskurt O . Effect of enhanced red blood cell aggregation on blood flow resistance in an isolated-perfused guinea pig heart preparation. Biorheology. 2005; 42(6):511-20. View

14.

Ernst E, Koenig W, Matrai A, Filipiak B, Stieber J . Blood rheology in healthy cigarette smokers. Results from the MONICA project, Augsburg. Arteriosclerosis. 1988; 8(4):385-8. DOI: 10.1161/01.atv.8.4.385. View

15.

Koenig W, Sund M, Ernst E, Mraz W, Hombach V, Keil U . Association between rheology and components of lipoproteins in human blood. Results from the MONICA project. Circulation. 1992; 85(6):2197-204. DOI: 10.1161/01.cir.85.6.2197. View

16.

Price J, Mowbray P, Lee A, Rumley A, Lowe G, Fowkes F . Relationship between smoking and cardiovascular risk factors in the development of peripheral arterial disease and coronary artery disease: Edinburgh Artery Study. Eur Heart J. 1999; 20(5):344-53. DOI: 10.1053/euhj.1998.1194. View

17.

Rampling M, Meiselman H, Neu B, Baskurt O . Influence of cell-specific factors on red blood cell aggregation. Biorheology. 2004; 41(2):91-112. View

18.

Sloop G, Garber D . The effects of low-density lipoprotein and high-density lipoprotein on blood viscosity correlate with their association with risk of atherosclerosis in humans. Clin Sci (Lond). 1997; 92(5):473-9. DOI: 10.1042/cs0920473. View

19.

Meiselman H, Merrill E, GILLILAND E, Pelletier G, Salzman E . Influence of plasma osmolarity on the rheology of human blood. J Appl Physiol. 1967; 22(4):772-81. DOI: 10.1152/jappl.1967.22.4.772. View

20.

Christy R, Baskurt O, Gass G, Gray A, Marshall-Gradisnik S . Erythrocyte aggregation and neutrophil function in an aging population. Gerontology. 2009; 56(2):175-80. DOI: 10.1159/000242461. View