Real-time Automatic Temperature Regulation During in Vivo MRI-guided Laser-induced Thermotherapy (MR-LITT)

Overview

Journal Sci Rep

Specialty Science

Date 2023 Feb 25

PMID 36841878

Authors

Manon Desclides

Valery Ozenne

Pierre Bour

Thibaut Faller

Guillaume Machinet

Christophe Pierre

Stephane Chemouny

Bruno Quesson

Affiliations

Soon will be listed here.

Abstract

Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature-time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT.

Citing Articles

Image-Based Monitoring of Thermal Ablation.

Wang X, Zhao S, Zhang A Bioengineering (Basel). 2025; 12(1).

PMID: 39851352 PMC: 11762831. DOI: 10.3390/bioengineering12010078.

Evaluation of a deformable image registration algorithm for image-guided thermal ablation of liver tumors on clinically acquired MR-temperature maps.

Ozenne V, Bour P, Faller T, Desclides M, Denis de Senneville B, Ocal O Med Phys. 2024; 52(2):722-736.

PMID: 39579154 PMC: 11788246. DOI: 10.1002/mp.17526.

Accuracy of 3D real-time MRI temperature mapping in gel phantoms during microwave heating.

Dietrich O, Lentini S, Ocal O, Bour P, Faller T, Ozenne V Eur Radiol Exp. 2024; 8(1):92.

PMID: 39143267 PMC: 11324620. DOI: 10.1186/s41747-024-00479-5.

Ultrasound Image Temperature Monitoring Based on a Temporal-Informed Neural Network.

Han Y, Du Y, He L, Meng X, Li M, Cao F Sensors (Basel). 2024; 24(15).

PMID: 39123982 PMC: 11314660. DOI: 10.3390/s24154934.

Safety and Efficacy of Laser Interstitial Thermal Therapy as Upfront Therapy in Primary Glioblastoma and IDH-Mutant Astrocytoma: A Meta-Analysis.

Pandey A, Chandla A, Mekonnen M, Hovis G, Teton Z, Patel K Cancers (Basel). 2024; 16(11).

PMID: 38893250 PMC: 11171930. DOI: 10.3390/cancers16112131.

References

Skandalakis G, Rivera D, Rizea C, Bouras A, Raj J, Bozec D . Hyperthermia treatment advances for brain tumors. Int J Hyperthermia. 2020; 37(2):3-19. PMC: 7756245. DOI: 10.1080/02656736.2020.1772512. View

Gong W, Wang Z, Liu N, Lin W, Wang X, Xu D . Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia. Biol Pharm Bull. 2011; 34(7):1058-64. DOI: 10.1248/bpb.34.1058. View

Dragonu I, de Oliveira P, Laurent C, Mougenot C, Grenier N, Moonen C . Non-invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry. NMR Biomed. 2009; 22(8):843-51. DOI: 10.1002/nbm.1397. View

Karampelas I, Sloan A . Laser-Induced Interstitial Thermotherapy of Gliomas. Prog Neurol Surg. 2018; 32:14-26. DOI: 10.1159/000469676. View

Salomir R, Rata M, Cadis D, Petrusca L, Auboiroux V, Cotton F . Endocavitary thermal therapy by MRI-guided phased-array contact ultrasound: experimental and numerical studies on the multi-input single-output PID temperature controller's convergence and stability. Med Phys. 2009; 36(10):4726-41. DOI: 10.1118/1.3215534. View

Deckers R, Quesson B, Arsaut J, Eimer S, Couillaud F, Moonen C . Image-guided, noninvasive, spatiotemporal control of gene expression. Proc Natl Acad Sci U S A. 2009; 106(4):1175-80. PMC: 2633569. DOI: 10.1073/pnas.0806936106. View

Atsumi H, Matsumae M, Kaneda M, Muro I, Mamata Y, Komiya T . Novel laser system and laser irradiation method reduced the risk of carbonization during laser interstitial thermotherapy: assessed by MR temperature measurement. Lasers Surg Med. 2001; 29(2):108-17. DOI: 10.1002/lsm.1096. View

De Landro M, Ianniello J, Yon M, Wolf A, Quesson B, Schena E . Fiber Bragg Grating Sensors for Performance Evaluation of Fast Magnetic Resonance Thermometry on Synthetic Phantom. Sensors (Basel). 2020; 20(22). PMC: 7696215. DOI: 10.3390/s20226468. View

Nguyen T, Park S, Hlaing K, Kang H . Temperature feedback-controlled photothermal treatment with diffusing applicator: theoretical and experimental evaluations. Biomed Opt Express. 2016; 7(5):1932-47. PMC: 4871092. DOI: 10.1364/BOE.7.001932. View

10.

Sebeke L, Deenen D, Maljaars E, Heijman E, de Jager B, Heemels W . Model predictive control for MR-HIFU-mediated, uniform hyperthermia. Int J Hyperthermia. 2019; 36(1):1040-1050. DOI: 10.1080/02656736.2019.1668065. View

11.

Mohammadi A, Schroeder J . Laser interstitial thermal therapy in treatment of brain tumors--the NeuroBlate System. Expert Rev Med Devices. 2014; 11(2):109-19. DOI: 10.1586/17434440.2014.882225. View

12.

Belykh E, Yagmurlu K, Martirosyan N, Lei T, Izadyyazdanabadi M, Malik K . Laser application in neurosurgery. Surg Neurol Int. 2017; 8:274. PMC: 5691557. DOI: 10.4103/sni.sni_489_16. View

13.

PENNES H . Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol. 1948; 1(2):93-122. DOI: 10.1152/jappl.1948.1.2.93. View

14.

Bianchi L, Cavarzan F, Ciampitti L, Cremonesi M, Grilli F, Saccomandi P . Thermophysical and mechanical properties of biological tissues as a function of temperature: a systematic literature review. Int J Hyperthermia. 2022; 39(1):297-340. DOI: 10.1080/02656736.2022.2028908. View

15.

Hall S, Ooi E, Payne S . Cell death, perfusion and electrical parameters are critical in models of hepatic radiofrequency ablation. Int J Hyperthermia. 2015; 31(5):538-50. PMC: 4776731. DOI: 10.3109/02656736.2015.1032370. View

16.

Sturesson C . Interstitial laser-induced thermotherapy: influence of carbonization on lesion size. Lasers Surg Med. 1998; 22(1):51-7. DOI: 10.1002/(sici)1096-9101(1998)22:1<51::aid-lsm12>3.0.co;2-b. View

17.

Korganbayev S, Orrico A, Bianchi L, De Landro M, Wolf A, Dostovalov A . Closed-Loop Temperature Control Based on Fiber Bragg Grating Sensors for Laser Ablation of Hepatic Tissue. Sensors (Basel). 2020; 20(22). PMC: 7697476. DOI: 10.3390/s20226496. View

18.

NDjin W, Burtnyk M, Lipsman N, Bronskill M, Kucharczyk W, Schwartz M . Active MR-temperature feedback control of dynamic interstitial ultrasound therapy in brain: in vivo experiments and modeling in native and coagulated tissues. Med Phys. 2014; 41(9):093301. DOI: 10.1118/1.4892923. View

19.

El-Brawany M, Nassiri D, terHaar G, Shaw A, Rivens I, Lozhken K . Measurement of thermal and ultrasonic properties of some biological tissues. J Med Eng Technol. 2009; 33(3):249-56. DOI: 10.1080/03091900802451265. View

20.

Quesson B, Vimeux F, Salomir R, de Zwart J, Moonen C . Automatic control of hyperthermic therapy based on real-time Fourier analysis of MR temperature maps. Magn Reson Med. 2002; 47(6):1065-72. DOI: 10.1002/mrm.10176. View