Interfacing Pain and Hunger

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2023 Feb 25

PMID 36841699

Authors

Qi Zhang

Michael J Krashes

Affiliations

Soon will be listed here.

Abstract

Calculating and selecting what sensory and homeostatic requirements to attend to at any given time is vital for animals' survival. Tang et al. uncovered a circuit emanating from excitatory cortical neurons that transmit nociceptive information via the hypothalamus to blunt appetite during periods of chronic pain.

References

Nagashima T, Tohyama S, Mikami K, Nagase M, Morishima M, Kasai A . Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice. Nat Commun. 2022; 13(1):7913. PMC: 9803671. DOI: 10.1038/s41467-022-35634-2. View

Olesen J . Some clinical features of the acute migraine attack. An analysis of 750 patients. Headache. 1978; 18(5):268-71. DOI: 10.1111/j.1526-4610.1978.hed1805268.x. View

Betley J, Xu S, Huang Cao Z, Gong R, Magnus C, Yu Y . Neurons for hunger and thirst transmit a negative-valence teaching signal. Nature. 2015; 521(7551):180-185. PMC: 4567040. DOI: 10.1038/nature14416. View

Alhadeff A, Su Z, Hernandez E, Klima M, Phillips S, Holland R . A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell. 2018; 173(1):140-152.e15. PMC: 5877408. DOI: 10.1016/j.cell.2018.02.057. View

Phua S, Tan Y, Kok A, Senol E, Chiam C, Lee C . A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception. Sci Adv. 2021; 7(19). PMC: 8104871. DOI: 10.1126/sciadv.abe4323. View

K Sutton Hickey A, Krashes M . Integrating Hunger with Rival Motivations. Trends Endocrinol Metab. 2020; 31(7):495-507. DOI: 10.1016/j.tem.2020.04.006. View

Atasoy D, Betley J, Su H, Sternson S . Deconstruction of a neural circuit for hunger. Nature. 2012; 488(7410):172-7. PMC: 3416931. DOI: 10.1038/nature11270. View

Jennings J, Rizzi G, Stamatakis A, Ung R, Stuber G . The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science. 2013; 341(6153):1517-21. PMC: 4131546. DOI: 10.1126/science.1241812. View

Tang H, Dong W, Hu R, Huang J, Huang Z, Xiong W . A neural circuit for the suppression of feeding under persistent pain. Nat Metab. 2022; 4(12):1746-1755. DOI: 10.1038/s42255-022-00688-5. View

10.

Mazzone C, Liang-Guallpa J, Li C, Wolcott N, Boone M, Southern M . High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nat Neurosci. 2020; 23(10):1253-1266. PMC: 7529959. DOI: 10.1038/s41593-020-0684-9. View

11.

Palmiter R . The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm. Trends Neurosci. 2018; 41(5):280-293. PMC: 5929477. DOI: 10.1016/j.tins.2018.03.007. View

12.

Burnett C, Li C, Webber E, Tsaousidou E, Xue S, Bruning J . Hunger-Driven Motivational State Competition. Neuron. 2016; 92(1):187-201. PMC: 5082717. DOI: 10.1016/j.neuron.2016.08.032. View