F-fluorodeoxyglucose (F-FDG) Functionalized Gold Nanoparticles (GNPs) for Plasmonic Photothermal Ablation of Cancer: A Review

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Feb 25

PMID 36839641

Authors

Mariano Pontico

Miriam Conte

Francesca Petronella

Viviana Frantellizzi

Maria Silvia De Feo

Dario Di Luzio

Roberto Pani

Giuseppe De Vincentis

Luciano De Sio

Affiliations

Soon will be listed here.

Abstract

The meeting and merging between innovative nanotechnological systems, such as nanoparticles, and the persistent need to outperform diagnostic-therapeutic approaches to fighting cancer are revolutionizing the medical research scenario, leading us into the world of nanomedicine. Photothermal therapy (PTT) is a non-invasive thermo-ablative treatment in which cellular hyperthermia is generated through the interaction of near-infrared light with light-to-heat converter entities, such as gold nanoparticles (GNPs). GNPs have great potential to improve recovery time, cure complexity, and time spent on the treatment of specific types of cancer. The development of gold nanostructures for photothermal efficacy and target selectivity ensures effective and deep tissue-penetrating PTT with fewer worries about adverse effects from nonspecific distributions. Regardless of the thriving research recorded in the last decade regarding the multiple biomedical applications of nanoparticles and, in particular, their conjugation with drugs, few works have been completed regarding the possibility of combining GNPs with the cancer-targeted pharmaceutical fluorodeoxyglucose (FDG). This review aims to provide an actual scenario on the application of functionalized GNP-mediated PTT for cancer ablation purposes, regarding the opportunity given by the F-fluorodeoxyglucose (F-FDG) functionalization.

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References

Frantellizzi V, Conte M, Pontico M, Pani A, Pani R, De Vincentis G . New Frontiers in Molecular Imaging with Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Efficacy, Toxicity, and Future Applications. Nucl Med Mol Imaging. 2020; 54(2):65-80. PMC: 7198685. DOI: 10.1007/s13139-020-00635-w. View

Jokerst J, Lobovkina T, Zare R, Gambhir S . Nanoparticle PEGylation for imaging and therapy. Nanomedicine (Lond). 2011; 6(4):715-28. PMC: 3217316. DOI: 10.2217/nnm.11.19. View

Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X . 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol. 2010; 67(4):899-910. PMC: 3093301. DOI: 10.1007/s00280-010-1391-0. View

De Angelis B, Depalo N, Petronella F, Quintarelli C, Curri M, Pani R . Stimuli-responsive nanoparticle-assisted immunotherapy: a new weapon against solid tumours. J Mater Chem B. 2020; 8(9):1823-1840. DOI: 10.1039/c9tb02246e. View

Chen H, Zhang X, Dai S, Ma Y, Cui S, Achilefu S . Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemo-therapy. Theranostics. 2013; 3(9):633-49. PMC: 3767113. DOI: 10.7150/thno.6630. View

Li J, Yu X, Jiang Y, He S, Zhang Y, Luo Y . Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy. Adv Mater. 2020; 33(4):e2003458. DOI: 10.1002/adma.202003458. View

Liu Y, Bhattarai P, Dai Z, Chen X . Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2018; 48(7):2053-2108. PMC: 6437026. DOI: 10.1039/c8cs00618k. View

Ban Q, Bai T, Duan X, Kong J . Noninvasive photothermal cancer therapy nanoplatforms via integrating nanomaterials and functional polymers. Biomater Sci. 2016; 5(2):190-210. DOI: 10.1039/c6bm00600k. View

Masood R, Roy I, Zu S, Hochstim C, Yong K, Law W . Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer. Integr Biol (Camb). 2011; 4(2):132-41. DOI: 10.1039/c1ib00060h. View

10.

Jiang X, Xin H, Ren Q, Gu J, Zhu L, Du F . Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment. Biomaterials. 2013; 35(1):518-29. DOI: 10.1016/j.biomaterials.2013.09.094. View

11.

Gao B, Shen L, He K, Xiao W . GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins. Int J Mol Med. 2015; 36(5):1282-90. PMC: 4601742. DOI: 10.3892/ijmm.2015.2358. View

12.

Grabbe S, Landfester K, Schuppan D, Barz M, Zentel R . Nanoparticles and the immune system: challenges and opportunities. Nanomedicine (Lond). 2016; 11(20):2621-2624. DOI: 10.2217/nnm-2016-0281. View

13.

Soenen S, Manshian B, Montenegro J, Amin F, Meermann B, Thiron T . Cytotoxic effects of gold nanoparticles: a multiparametric study. ACS Nano. 2012; 6(7):5767-83. DOI: 10.1021/nn301714n. View

14.

Zhao N, Yang Z, Li B, Meng J, Shi Z, Li P . RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy. Int J Nanomedicine. 2016; 11:5595-5610. PMC: 5089827. DOI: 10.2147/IJN.S104034. View

15.

Aydogan B, Li J, Rajh T, Chaudhary A, Chmura S, Pelizzari C . AuNP-DG: deoxyglucose-labeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging. Mol Imaging Biol. 2010; 12(5):463-7. DOI: 10.1007/s11307-010-0299-8. View

16.

Loo C, Lowery A, Halas N, West J, Drezek R . Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 2005; 5(4):709-11. DOI: 10.1021/nl050127s. View

17.

Faid A, Shouman S, Badr Y, Sharaky M, Mostafa E, Sliem M . Gold nanoparticles loaded chitosan encapsulate 6-mercaptopurine as a novel nanocomposite for chemo-photothermal therapy on breast cancer. BMC Chem. 2022; 16(1):94. PMC: 9656029. DOI: 10.1186/s13065-022-00892-0. View

18.

Onaciu A, Braicu C, Zimta A, Moldovan A, Stiufiuc R, Buse M . Gold nanorods: from anisotropy to opportunity. An evolution update. Nanomedicine (Lond). 2019; 14(9):1203-1226. DOI: 10.2217/nnm-2018-0409. View

19.

Ying H, Wang H, Jiang G, Tang H, Li L, Zhang J . Injectable agarose hydrogels and doxorubicin-encapsulated iron-gallic acid nanoparticles for chemodynamic-photothermal synergistic therapy against osteosarcoma. Front Chem. 2022; 10:1045612. PMC: 9663816. DOI: 10.3389/fchem.2022.1045612. View

20.

Fang J, Nakamura H, Maeda H . The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev. 2010; 63(3):136-51. DOI: 10.1016/j.addr.2010.04.009. View