T Cell Response to SARS-CoV-2 Coinfection and Comorbidities

Overview

Journal Pathogens

Date 2023 Feb 25

PMID 36839596

Authors

Liqing Wang

Hao-Yun Peng

Aspen Pham

Eber Villazana

Darby J Ballard

Jugal Kishore Das

Anil Kumar

Xiaofang Xiong

Jianxun Song

Affiliations

Soon will be listed here.

Abstract

For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.

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