Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Feb 25

PMID 36835929

Authors

Aina Brunet

Javier Milara

Soledad Frias

Julio Cortijo

Miguel Armengot

Affiliations

Soon will be listed here.

Abstract

(1) Background: Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients' QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance ( = 0.04) and the endoscopic polyp score ( = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia ( = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP.

References

Soler Z, Sauer D, Mace J, Smith T . Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2009; 141(4):454-61. PMC: 2766519. DOI: 10.1016/j.otohns.2009.06.085. View

Gitomer S, Fountain C, Kingdom T, Getz A, Sillau S, Katial R . Clinical Examination of Tissue Eosinophilia in Patients with Chronic Rhinosinusitis and Nasal Polyposis. Otolaryngol Head Neck Surg. 2016; 155(1):173-8. DOI: 10.1177/0194599816637856. View

Rosati D, Rosato C, Pagliuca G, Cerbelli B, Della Rocca C, Di Cristofano C . Predictive markers of long-term recurrence in chronic rhinosinusitis with nasal polyps. Am J Otolaryngol. 2019; 41(1):102286. DOI: 10.1016/j.amjoto.2019.102286. View

Soler Z, Sauer D, Mace J, Smith T . Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery. Otolaryngol Head Neck Surg. 2010; 142(1):64-71. PMC: 2811855. DOI: 10.1016/j.otohns.2009.10.005. View

Matsuwaki Y, Ookushi T, Asaka D, Mori E, Nakajima T, Yoshida T . Chronic rhinosinusitis: risk factors for the recurrence of chronic rhinosinusitis based on 5-year follow-up after endoscopic sinus surgery. Int Arch Allergy Immunol. 2008; 146 Suppl 1:77-81. DOI: 10.1159/000126066. View

Stevens W, Peters A, Hirsch A, Nordberg C, Schwartz B, Mercer D . Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2017; 5(4):1061-1070.e3. PMC: 5503772. DOI: 10.1016/j.jaip.2016.12.027. View

Wei B, Liu F, Zhang J, Liu Y, Du J, Liu S . Multivariate analysis of inflammatory endotypes in recurrent nasal polyposis in a Chinese population. Rhinology. 2018; 56(3):216-226. DOI: 10.4193/Rhin17.240. View

Abdalla S, Alreefy H, Hopkins C . Prevalence of sinonasal outcome test (SNOT-22) symptoms in patients undergoing surgery for chronic rhinosinusitis in the England and Wales National prospective audit. Clin Otolaryngol. 2012; 37(4):276-82. DOI: 10.1111/j.1749-4486.2012.02527.x. View

Thompson C, Price C, Huang J, Min J, Suh L, Shintani-Smith S . A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015; 6(5):500-7. PMC: 4856570. DOI: 10.1002/alr.21687. View

10.

Harlin S, Ansel D, Lane S, Myers J, Kephart G, Gleich G . A clinical and pathologic study of chronic sinusitis: the role of the eosinophil. J Allergy Clin Immunol. 1988; 81(5 Pt 1):867-75. DOI: 10.1016/0091-6749(88)90944-x. View

11.

Snidvongs K, Lam M, Sacks R, Earls P, Kalish L, Phillips P . Structured histopathology profiling of chronic rhinosinusitis in routine practice. Int Forum Allergy Rhinol. 2012; 2(5):376-85. DOI: 10.1002/alr.21032. View

12.

Fokkens W . EPOS2020: a major step forward. Rhinology. 2020; 58(1):1. DOI: 10.4193/Rhin20.401. View

13.

Lund V, Mackay I . Staging in rhinosinusitus. Rhinology. 1993; 31(4):183-4. View

14.

Mace J, Michael Y, Carlson N, Litvack J, Smith T . Correlations between endoscopy score and quality of life changes after sinus surgery. Arch Otolaryngol Head Neck Surg. 2010; 136(4):340-6. PMC: 2860109. DOI: 10.1001/archoto.2010.34. View

15.

Wohrl S . NSAID hypersensitivity - recommendations for diagnostic work up and patient management. Allergo J Int. 2018; 27(4):114-121. PMC: 6004000. DOI: 10.1007/s40629-018-0064-0. View

16.

Suzuki H, Takahashi Y, Wataya H, Ikeda K, Nakabayashi S, Shimomura A . Mechanism of neutrophil recruitment induced by IL-8 in chronic sinusitis. J Allergy Clin Immunol. 1996; 98(3):659-70. DOI: 10.1016/s0091-6749(96)70100-8. View

17.

Kuhar H, Tajudeen B, Mahdavinia M, Gattuso P, Ghai R, Batra P . Inflammatory infiltrate and mucosal remodeling in chronic rhinosinusitis with and without polyps: structured histopathologic analysis. Int Forum Allergy Rhinol. 2017; 7(7):679-689. DOI: 10.1002/alr.21943. View

18.

Armengot M, Garin L, de Lamo M, Krause F, Carda C . Cytological and tissue eosinophilia correlations in nasal polyposis. Am J Rhinol Allergy. 2010; 24(6):413-5. DOI: 10.2500/ajra.2010.24.3549. View

19.

Zhang Y, Gevaert E, Lou H, Wang X, Zhang L, Bachert C . Chronic rhinosinusitis in Asia. J Allergy Clin Immunol. 2017; 140(5):1230-1239. DOI: 10.1016/j.jaci.2017.09.009. View

20.

Vlaminck S, Vauterin T, Hellings P, Jorissen M, Acke F, van Cauwenberge P . The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3-year prospective observational study. Am J Rhinol Allergy. 2014; 28(3):260-4. DOI: 10.2500/ajra.2014.28.4024. View