Chemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Feb 25

PMID 36833336

Authors

Yusen Qiao

Jun Li

Catherine Yuh

Frank Ko

Louis G Mercuri

Jad Alkhudari

Robin Pourzal

Chun-do Oh

Affiliations

Soon will be listed here.

Abstract

Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures. Therefore, enhancing our understanding of chemokines is critical for developing appropriate treatment of TMJ. In this review, we discuss chemokines including MCP-1, MIP-1α, MIP-3a, RANTES, IL-8, SDF-1, and fractalkine that are known to be involved in TMJ diseases. In addition, we present novel findings that CCL2 is involved in β-catenin-mediated TMJ osteoarthritis (OA) and potential molecular targets for the development of effective therapies. The effects of common inflammatory factors, IL-1β and TNF-α, on chemotaxis are also described. In conclusion, this review aims to provide a theoretical basis for future chemokine-targeted therapies for TMJ OA.

Citing Articles

Association between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.

Ding A, Yu C, Jiang F, Wu C, Zhao J J Appl Oral Sci. 2025; 32():e20240112.

PMID: 39813538 PMC: 11756819. DOI: 10.1590/1678-7757-2024-0112.

Identification of potential immune-related genes and infiltrations in temporomandibular joint osteoarthritis.

Zhu M, Xing M, Sun R, Li M, Qian W, Fan M Ann Med Surg (Lond). 2024; 86(12):7135-7146.

PMID: 39649914 PMC: 11623849. DOI: 10.1097/MS9.0000000000002682.

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