Circulating MiR-451a Expression May Predict Recurrence in Atrial Fibrillation Patients After Catheter Pulmonary Vein Ablation

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2023 Feb 25

PMID 36831306

Authors

Ricardo Lage

Maria Cebro-Marquez

Marta E Vilar-Sanchez

Laila Gonzalez-Melchor

Javier Garcia-Seara

Jose Luis Martinez-Sande

Xesus Alberte Fernandez-Lopez

Alana Aragon-Herrera

Maria Amparo Martinez-Monzonis

Jose Ramon Gonzalez-Juanatey

Moises Rodriguez-Manero

Isabel Moscoso

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation is the most prevalent tachyarrhythmia in clinical practice, with very high cardiovascular morbidity and mortality with a high-cost impact in health systems. Currently, it is one of the main causes of stroke and subsequent heart failure and sudden death. miRNAs mediate in several processes involved in cardiovascular disease, including fibrosis and electrical and structural remodeling. Several studies suggest a key role of miRNAs in the course and maintenance of atrial fibrillation. In our study, we aimed to identify the differential expression of circulating miRNAs and their predictive value as biomarkers of recurrence in atrial fibrillation patients undergoing catheter pulmonary vein ablation. To this effect, 42 atrial fibrillation patients were recruited for catheter ablation. We measured the expression of 84 miRNAs in non-recurrent and recurrent groups (45.2%), both in plasma from peripheral and left atrium blood. Expression analysis showed that miRNA-451a is downregulated in recurrent patients. Receiver operating characteristic curve analysis showed that miR-451a in left atrium plasma could predict atrial fibrillation recurrence after pulmonary vein isolation. In addition, atrial fibrillation recurrence is positively associated with the increment of scar percentage. Our data suggest that miRNA-451a expression plays an important role in AF recurrence by controlling fibrosis and progression.

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