Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): The Future of Human and Veterinary Regenerative Medicine

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Feb 25

PMID 36831171

Authors

Maria Gemma Velasco

Katy Satue

Deborah Chicharro

Emma Martins

Marta Torres-Torrillas

Pau Pelaez

Laura Miguel-Pastor

Ayla Del Romero

Elena Damia

Belen Cuervo

Jose Maria Carrillo

Ramon Cugat

Joaquin Jesus Sopena

Monica Rubio

Affiliations

Soon will be listed here.

Abstract

In recent years, several studies have been conducted on Muse cells mainly due to their pluripotency, high tolerance to stress, self-renewal capacity, ability to repair DNA damage and not being tumoral. Additionally, since these stem cells can be isolated from different tissues in the adult organism, obtaining them is not considered an ethical problem, providing an advantage over embryonic stem cells. Regarding their therapeutic potential, few studies have reported clinical applications in the treatment of different diseases, such as aortic aneurysm and chondral injuries in the mouse or acute myocardial infarction in the swine, rabbit, sheep and in humans. This review aims to describe the characterization of Muse cells, show their biological characteristics, explain the differences between Muse cells and mesenchymal stem cells, and present their contribution to the treatment of some diseases.

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