Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Feb 25

PMID 36830891

Authors

Tariq Aziz

Abad Ali Nadeem

Abid Sarwar

Ishrat Perveen

Nageen Hussain

Ayaz Ali Khan

Zubaida Daudzai

Haiying Cui

Lin Lin

Affiliations

Soon will be listed here.

Abstract

Aging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily focuses on aging genetics, physical parameters, and the use of nanoparticles as delivery systems of drugs and vaccines via the nasal cavity. Studies have identified various genes involved in centenarian and average-aged people. VEGF is a key mediator involved in angiogenesis. Different therapeutic approaches induce vascular function and angiogenesis. FOLR1 gene codes for folate receptor alpha protein that helps in regulating the transport of vitamin B folate, 5-methyltetrahydrofolate and folate analogs inside the cell. This gene also aids in slowing the aging process down by cellular regeneration and promotes healthy aging by reducing aging symptoms. It has been found through the literature that GATA 6, Yamanaka factors, and FOLR1 work in synchronization to induce healthy and delayed aging. The role and applications of genes including CBS, CISD, SIRT 1, and SIRT 6 play a significant role in aging.

Citing Articles

Exploring Natural Compounds as Potential CDK4 Inhibitors for Therapeutic Intervention in Neurodegenerative Diseases through Computational Analysis.

Rani N, Kumar P Mol Biotechnol. 2024; .

PMID: 39207668 DOI: 10.1007/s12033-024-01258-8.

2D Materials Nanoarchitectonics for 3D Structures/Functions.

Ariga K Materials (Basel). 2024; 17(4).

PMID: 38399187 PMC: 10890396. DOI: 10.3390/ma17040936.

Materials Nanoarchitectonics at Dynamic Interfaces: Structure Formation and Functional Manipulation.

Ariga K Materials (Basel). 2024; 17(1).

PMID: 38204123 PMC: 10780059. DOI: 10.3390/ma17010271.

Immobilization of Aspergillus oryzae tyrosine hydroxylase on ZnO nanocrystals for improved stability and catalytic efficiency towards L-dopa production.

Khalid A, Ali S, Rukhma , Jahangeer M, Sarwar A, Nelofer R Sci Rep. 2023; 13(1):22882.

PMID: 38129644 PMC: 10739923. DOI: 10.1038/s41598-023-50198-x.

Synthesis of Iron Oxide Nanoparticles from Plant Extract and Assessment of Their Cytotoxic, Antioxidant, Anti-Inflammatory, and Anti-Diabetic Properties via Different Nanoinformatics Approaches.

Shabbir M, Naveed M, Rehman S, Ain N, Aziz T, Alharbi M ACS Omega. 2023; 8(37):33358-33366.

PMID: 37744851 PMC: 10515396. DOI: 10.1021/acsomega.3c02744.

References

Rahman M, Islam M, Shohag S, Hossain M, Rahaman M, Islam F . The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review. Molecules. 2022; 27(5). PMC: 8911649. DOI: 10.3390/molecules27051713. View

Naveed M, Saad Mughal M, Jabeen K, Aziz T, Naz S, Nazir N . Evaluation of the whole proteome to design a novel mRNA-based vaccine against multidrug-resistant . Front Microbiol. 2022; 13:960285. PMC: 9624125. DOI: 10.3389/fmicb.2022.960285. View

Hayat P, Khan I, Rehman A, Jamil T, Hayat A, Rehman M . Myogenesis and Analysis of Antimicrobial Potential of Silver Nanoparticles (AgNPs) against Pathogenic Bacteria. Molecules. 2023; 28(2). PMC: 9863364. DOI: 10.3390/molecules28020637. View

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D . Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13:757-772. PMC: 5927356. DOI: 10.2147/CIA.S158513. View

Wlaschek M, Tantcheva-Poor I, Naderi L, Ma W, Schneider L, Schuller J . Solar UV irradiation and dermal photoaging. J Photochem Photobiol B. 2001; 63(1-3):41-51. DOI: 10.1016/s1011-1344(01)00201-9. View

Kervinen K, Savolainen M, Salokannel J, Hynninen A, Heikkinen J, Ehnholm C . Apolipoprotein E and B polymorphisms--longevity factors assessed in nonagenarians. Atherosclerosis. 1994; 105(1):89-95. DOI: 10.1016/0021-9150(94)90011-6. View

Naveed M, Sheraz M, Amin A, Waseem M, Aziz T, Khan A . Designing a Novel Peptide-Based Multi-Epitope Vaccine to Evoke a Robust Immune Response against Pathogenic Multidrug-Resistant . Vaccines (Basel). 2022; 10(8). PMC: 9413917. DOI: 10.3390/vaccines10081300. View

Holmes D, Zachary I . The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol. 2005; 6(2):209. PMC: 551528. DOI: 10.1186/gb-2005-6-2-209. View

Khombi Shooshtari M, Moazedi A, Parham G . Memory and motor coordination improvement by folic Acid supplementation in healthy adult male rats. Iran J Basic Med Sci. 2013; 15(6):1173-9. PMC: 3646228. View

10.

Renu S, Renukaradhya G . Chitosan Nanoparticle Based Mucosal Vaccines Delivered Against Infectious Diseases of Poultry and Pigs. Front Bioeng Biotechnol. 2020; 8:558349. PMC: 7691491. DOI: 10.3389/fbioe.2020.558349. View

11.

Dhakal S, Renu S, Ghimire S, Lakshmanappa Y, Hogshead B, Feliciano-Ruiz N . Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs. Front Immunol. 2018; 9:934. PMC: 5940749. DOI: 10.3389/fimmu.2018.00934. View

12.

Lopez-Otin C, Blasco M, Partridge L, Serrano M, Kroemer G . The hallmarks of aging. Cell. 2013; 153(6):1194-217. PMC: 3836174. DOI: 10.1016/j.cell.2013.05.039. View

13.

Colombini B, Dinu M, Murgo E, Lotti S, Tarquini R, Sofi F . Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock. Antioxidants (Basel). 2022; 11(11). PMC: 9686908. DOI: 10.3390/antiox11112228. View

14.

Polito F, Marini H, Bitto A, Irrera N, Vaccaro M, Adamo E . Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats. Br J Pharmacol. 2011; 165(4):994-1005. PMC: 3312494. DOI: 10.1111/j.1476-5381.2011.01619.x. View

15.

Pandareesh M, Mythri R, Srinivas Bharath M . Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases. Neurochem Int. 2015; 89:198-208. DOI: 10.1016/j.neuint.2015.07.003. View

16.

Lahteenvuo J, Rosenzweig A . Effects of aging on angiogenesis. Circ Res. 2012; 110(9):1252-64. PMC: 4101916. DOI: 10.1161/CIRCRESAHA.111.246116. View

17.

Zhao R, Guo Z, Zhang R, Deng C, Xu J, Dong W . Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation. J Appl Toxicol. 2017; 38(5):678-687. DOI: 10.1002/jat.3573. View

18.

Geesaman B, Benson E, Brewster S, Kunkel L, Blanche H, Thomas G . Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. Proc Natl Acad Sci U S A. 2003; 100(24):14115-20. PMC: 283555. DOI: 10.1073/pnas.1936249100. View

19.

Guo Y, He P, Feng A . Effect of curcumin on expressions of NF-κBp65, TNF-α and IL-8 in placental tissue of premature birth of infected mice. Asian Pac J Trop Med. 2017; 10(2):175-178. DOI: 10.1016/j.apjtm.2017.01.004. View

20.

Serfling S, Zhi Y, Schirbel A, Lindner T, Meyer T, Gerhard-Hartmann E . Improved cancer detection in Waldeyer's tonsillar ring by Ga-FAPI PET/CT imaging. Eur J Nucl Med Mol Imaging. 2020; 48(4):1178-1187. PMC: 8041699. DOI: 10.1007/s00259-020-05055-8. View