Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs

Overview

Journal Animals (Basel)

Date 2023 Feb 25

PMID 36830411

Authors

Kwang-Soo Lyoo

Yoon-Hwan Yeo

Sung-Geun Lee

Minjoo Yeom

Joo-Yeon Lee

Kyung-Chang Kim

Daesub Song

Affiliations

Soon will be listed here.

Abstract

The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet owners. Here, we experimentally inoculated beagle dogs with SARS-CoV-2 or Middle East respiratory syndrome (MERS-CoV) to compare their susceptibility to and the pathogenicity of these viruses. The dogs in this study exhibited weight loss and increased body temperatures and shed the viruses in their nasal secretions, feces, and urine. Pathologic changes were observed in the lungs of the dogs inoculated with SARS-CoV-2 or MERS-CoV. Additionally, clinical characteristics of SARS-CoV-2, such as increased lactate dehydrogenase levels, were identified in the current study.

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