Innate Immune Responses in Pneumonia

Overview

Journal Pneumonia (Nathan)

Publisher Biomed Central

Date 2023 Feb 24

PMID 36829255

Authors

Filiz T Korkmaz

Katrina E Traber

Affiliations

Soon will be listed here.

Abstract

The lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of pathogens and response to pollutants is required to prevent overwhelming infection, while preventing tissue damage and maintaining efficient gas exchange. Broadly, the innate immune system is the collection of immediate, intrinsic immune responses to pathogen or tissue injury. In this review, we will examine the innate immune responses of the lung, with a particular focus on their role in pneumonia. We will discuss the anatomic barriers and antimicrobial proteins of the lung, pathogen and injury recognition, and the role of leukocytes (macrophages, neutrophils, and innate lymphocytes) and lung stromal cells in innate immunity. Throughout the review, we will focus on new findings in innate immunity as well as features that are unique to the lung.

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References

Umehara T, Kato K, Park Y, Lillehoj E, Kawauchi H, Kim K . Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection. Inflamm Res. 2012; 61(9):1013-20. PMC: 3419284. DOI: 10.1007/s00011-012-0494-y. View

Mata-Martinez P, Bergon-Gutierrez M, Del Fresno C . Dectin-1 Signaling Update: New Perspectives for Trained Immunity. Front Immunol. 2022; 13:812148. PMC: 8882614. DOI: 10.3389/fimmu.2022.812148. View

Peiro T, Patel D, Akthar S, Gregory L, Pyle C, Harker J . Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection. Thorax. 2017; 73(6):546-556. PMC: 5969338. DOI: 10.1136/thoraxjnl-2017-210010. View

Armstrong S, Darwish I, Lee W . Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection. Virulence. 2013; 4(6):537-42. PMC: 5359731. DOI: 10.4161/viru.25779. View

Jones B, Herman D, Dela Cruz C, Waterer G, Metlay J, Ruminjo J . Summary for Clinicians: Clinical Practice Guideline for the Diagnosis and Treatment of Community-acquired Pneumonia. Ann Am Thorac Soc. 2019; 17(2):133-138. DOI: 10.1513/AnnalsATS.201909-704CME. View

Schneider C, Nobs S, Kurrer M, Rehrauer H, Thiele C, Kopf M . Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat Immunol. 2014; 15(11):1026-37. DOI: 10.1038/ni.3005. View

Storek K, Gertsvolf N, Ohlson M, Monack D . cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. J Immunol. 2015; 194(7):3236-45. PMC: 4367159. DOI: 10.4049/jimmunol.1402764. View

Kok W, Denney L, Benam K, Cole S, Clelland C, McMichael A . Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol. 2011; 91(3):357-68. DOI: 10.1189/jlb.0411184. View

Ghosh S, Gregory D, Smith A, Kobzik L . MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Am J Respir Cell Mol Biol. 2011; 45(5):1036-44. PMC: 3262690. DOI: 10.1165/rcmb.2010-0349OC. View

10.

Bhattacharya J, Westphalen K . Macrophage-epithelial interactions in pulmonary alveoli. Semin Immunopathol. 2016; 38(4):461-9. PMC: 5018989. DOI: 10.1007/s00281-016-0569-x. View

11.

Wong C, Smith C, Sakamoto K, Kaminski N, Koff J, Goldstein D . Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. J Immunol. 2017; 199(3):1060-1068. PMC: 5557035. DOI: 10.4049/jimmunol.1700397. View

12.

Areschoug T, Gordon S . Scavenger receptors: role in innate immunity and microbial pathogenesis. Cell Microbiol. 2009; 11(8):1160-9. DOI: 10.1111/j.1462-5822.2009.01326.x. View

13.

Lee Y, Wang H, Starrett G, Phuong V, Jameson S, Hogquist K . Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response. Immunity. 2015; 43(3):566-78. PMC: 4575275. DOI: 10.1016/j.immuni.2015.06.025. View

14.

Burns A, Smith C, Walker D . Unique structural features that influence neutrophil emigration into the lung. Physiol Rev. 2003; 83(2):309-36. DOI: 10.1152/physrev.00023.2002. View

15.

Niethamer T, Stabler C, Leach J, Zepp J, Morley M, Babu A . Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury. Elife. 2020; 9. PMC: 7176435. DOI: 10.7554/eLife.53072. View

16.

Zahid A, Ismail H, Li B, Jin T . Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity. Front Immunol. 2020; 11:613039. PMC: 7734173. DOI: 10.3389/fimmu.2020.613039. View

17.

Roquilly A, Jacqueline C, Davieau M, Molle A, Sadek A, Fourgeux C . Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat Immunol. 2020; 21(6):636-648. DOI: 10.1038/s41590-020-0673-x. View

18.

Lin W, Gowdy K, Madenspacher J, Zemans R, Yamamoto K, Lyons-Cohen M . Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2019; 130(1):157-170. PMC: 6934223. DOI: 10.1172/JCI127144. View

19.

Caruso R, Warner N, Inohara N, Nunez G . NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity. 2014; 41(6):898-908. PMC: 4272446. DOI: 10.1016/j.immuni.2014.12.010. View

20.

Hiruma T, Tsuyuzaki H, Uchida K, Trapnell B, Yamamura Y, Kusakabe Y . IFN-β Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality. Am J Respir Cell Mol Biol. 2018; 59(1):45-55. PMC: 6835072. DOI: 10.1165/rcmb.2017-0261OC. View