Labeling T Cells to Track Immune Response to Immunotherapy in Glioblastoma

Overview

Journal Tomography

Publisher MDPI

Specialty Radiology

Date 2023 Feb 24

PMID 36828374

Authors

John Y Rhee

Jack Y Ghannam

Bryan D Choi

Elizabeth R Gerstner

Affiliations

Soon will be listed here.

Abstract

While the advent of immunotherapy has revolutionized cancer treatment, its use in the treatment of glioblastoma (GBM) has been less successful. Most studies using immunotherapy in GBM have been negative and the reasons for this are still being studied. In clinical practice, interpreting response to immunotherapy has been challenging, particularly when trying to differentiate between treatment-related changes (i.e., pseudoprogression) or true tumor progression. T cell tagging is one promising technique to noninvasively monitor treatment efficacy by assessing the migration, expansion, and engagement of T cells and their ability to target tumor cells at the tumor site.

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References

Bailly C, Gouard S, Lacombe M, Saec P, Chalopin B, Bourgeois M . Comparison of Immuno-PET of CD138 and PET imaging with CuCl and F-FDG in a preclinical syngeneic model of multiple myeloma. Oncotarget. 2018; 9(10):9061-9072. PMC: 5823645. DOI: 10.18632/oncotarget.23886. View

Markovic S, Galli F, Suman V, Nevala W, Paulsen A, Hung J . Non-invasive visualization of tumor infiltrating lymphocytes in patients with metastatic melanoma undergoing immune checkpoint inhibitor therapy: a pilot study. Oncotarget. 2018; 9(54):30268-30278. PMC: 6084386. DOI: 10.18632/oncotarget.25666. View

Wen P, Reardon D, Armstrong T, Phuphanich S, Aiken R, Landolfi J . A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma. Clin Cancer Res. 2019; 25(19):5799-5807. PMC: 8132111. DOI: 10.1158/1078-0432.CCR-19-0261. View

Natarajan A, Mayer A, Xu L, Reeves R, Gano J, Gambhir S . Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes. Bioconjug Chem. 2015; 26(10):2062-9. DOI: 10.1021/acs.bioconjchem.5b00318. View

Gibson H, McKnight B, Malysa A, Dyson G, Wiesend W, McCarthy C . IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy. Cancer Res. 2018; 78(19):5706-5717. PMC: 6443251. DOI: 10.1158/0008-5472.CAN-18-0253. View

Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J . Structural and functional features of central nervous system lymphatic vessels. Nature. 2015; 523(7560):337-41. PMC: 4506234. DOI: 10.1038/nature14432. View

Bansal A, Pandey M, Demirhan Y, Nesbitt J, Crespo-Diaz R, Terzic A . Novel (89)Zr cell labeling approach for PET-based cell trafficking studies. EJNMMI Res. 2015; 5:19. PMC: 4401478. DOI: 10.1186/s13550-015-0098-y. View

Park J, Kim C, Shim J, Kim J, Lee H, Lee J . Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma. Oncoimmunology. 2018; 8(1):e1525243. PMC: 6287793. DOI: 10.1080/2162402X.2018.1525243. View

Griessinger C, Maurer A, Kesenheimer C, Kehlbach R, Reischl G, Ehrlichmann W . 64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET. Proc Natl Acad Sci U S A. 2015; 112(4):1161-6. PMC: 4313850. DOI: 10.1073/pnas.1418391112. View

10.

Larimer B, Wehrenberg-Klee E, Caraballo A, Mahmood U . Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy. J Nucl Med. 2016; 57(10):1607-1611. PMC: 5367446. DOI: 10.2967/jnumed.116.173930. View

11.

Zheng B, Vazin T, Goodwill P, Conway A, Verma A, Saritas E . Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast. Sci Rep. 2015; 5:14055. PMC: 4566119. DOI: 10.1038/srep14055. View

12.

Perrin J, Capitao M, Mougin-Degraef M, Guerard F, Faivre-Chauvet A, Rbah-Vidal L . Cell Tracking in Cancer Immunotherapy. Front Med (Lausanne). 2020; 7:34. PMC: 7033605. DOI: 10.3389/fmed.2020.00034. View

13.

Martinez O, Sosabowski J, Maher J, Papa S . New Developments in Imaging Cell-Based Therapy. J Nucl Med. 2019; 60(6):730-735. PMC: 6581223. DOI: 10.2967/jnumed.118.213348. View

14.

Alam I, Mayer A, Sagiv-Barfi I, Wang K, Vermesh O, Czerwinski D . Imaging activated T cells predicts response to cancer vaccines. J Clin Invest. 2018; 128(6):2569-2580. PMC: 5983309. DOI: 10.1172/JCI98509. View

15.

Omuro A, Brandes A, Carpentier A, Idbaih A, Reardon D, Cloughesy T . Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. Neuro Oncol. 2022; 25(1):123-134. PMC: 9825306. DOI: 10.1093/neuonc/noac099. View

16.

Choi B, Curry W, Carter B, Maus M . Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons. Neurosurg Focus. 2018; 44(6):E13. DOI: 10.3171/2018.2.FOCUS17788. View

17.

Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I . A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature. 2021; 592(7854):463-468. PMC: 8046668. DOI: 10.1038/s41586-021-03363-z. View

18.

Beckford Vera D, Smith C, Bixby L, Glatt D, Dunn S, Saito R . Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors. PLoS One. 2018; 13(3):e0193832. PMC: 5841805. DOI: 10.1371/journal.pone.0193832. View

19.

Bhargava K, Gupta R, Nichols K, Palestro C . In vitro human leukocyte labeling with (64)Cu: an intraindividual comparison with (111)In-oxine and (18)F-FDG. Nucl Med Biol. 2009; 36(5):545-9. PMC: 2695937. DOI: 10.1016/j.nucmedbio.2009.03.001. View

20.

Niemeijer A, Leung D, Huisman M, Bahce I, Hoekstra O, van Dongen G . Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer. Nat Commun. 2018; 9(1):4664. PMC: 6220188. DOI: 10.1038/s41467-018-07131-y. View