» Articles » PMID: 36826258

Application of Hydrogels As Three-Dimensional Bioprinting Ink for Tissue Engineering

Overview
Journal Gels
Date 2023 Feb 24
PMID 36826258
Authors
Affiliations
Soon will be listed here.
Abstract

The use of three-dimensional bioprinting technology combined with the principle of tissue engineering is important for the construction of tissue or organ regeneration microenvironments. As a three-dimensional bioprinting ink, hydrogels need to be highly printable and provide a stiff and cell-friendly microenvironment. At present, hydrogels are used as bioprinting inks in tissue engineering. However, there is still a lack of summary of the latest 3D printing technology and the properties of hydrogel materials. In this paper, the materials commonly used as hydrogel bioinks; the advanced technologies including inkjet bioprinting, extrusion bioprinting, laser-assisted bioprinting, stereolithography bioprinting, suspension bioprinting, and digital 3D bioprinting technologies; printing characterization including printability and fidelity; biological properties, and the application fields of bioprinting hydrogels in bone tissue engineering, skin tissue engineering, cardiovascular tissue engineering are reviewed, and the current problems and future directions are prospected.

Citing Articles

Extrusion-Based 3D Printing of Pharmaceuticals-Evaluating Polymer (Sodium Alginate, HPC, HPMC)-Based Ink's Suitability by Investigating Rheology.

Rony F, Kimbell G, Serrano T, Clay D, Ilias S, Azad M Micromachines (Basel). 2025; 16(2).

PMID: 40047629 PMC: 11857113. DOI: 10.3390/mi16020163.


Enhancing auricular reconstruction: A biomimetic scaffold with 3D-printed multiscale porous structure utilizing chondrogenic activity ink.

Kong Y, Lu Z, Zhan J, Zhou X, Chen S, Chen Q Mater Today Bio. 2025; 31:101516.

PMID: 39968521 PMC: 11834130. DOI: 10.1016/j.mtbio.2025.101516.


Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications.

Toader C, Dumitru A, Eva L, Serban M, Covache-Busuioc R, Ciurea A Int J Mol Sci. 2025; 25(24.

PMID: 39769066 PMC: 11676454. DOI: 10.3390/ijms252413302.


Effective and new technologies in kidney tissue engineering.

Rayat Pisheh H, Haghdel M, Jahangir M, Hoseinian M, Rostami Yasuj S, Roodbari A Front Bioeng Biotechnol. 2024; 12:1476510.

PMID: 39479295 PMC: 11521926. DOI: 10.3389/fbioe.2024.1476510.


Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review.

Parvin N, Kumar V, Joo S, Mandal T Materials (Basel). 2024; 17(19).

PMID: 39410363 PMC: 11477805. DOI: 10.3390/ma17194792.


References
1.
Hauser P, Chang H, Nishikawa M, Kimura H, Yanagawa N, Hamon M . Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization. Bioengineering (Basel). 2021; 8(11). PMC: 8615027. DOI: 10.3390/bioengineering8110178. View

2.
de Melo B, Jodat Y, Cruz E, C Benincasa J, Shin S, Porcionatto M . Strategies to use fibrinogen as bioink for 3D bioprinting fibrin-based soft and hard tissues. Acta Biomater. 2020; 117:60-76. DOI: 10.1016/j.actbio.2020.09.024. View

3.
Liu W, Zhang Y, Heinrich M, De Ferrari F, Lin Jang H, Bakht S . Rapid Continuous Multimaterial Extrusion Bioprinting. Adv Mater. 2016; 29(3). PMC: 5235978. DOI: 10.1002/adma.201604630. View

4.
Unagolla J, Jayasuriya A . Hydrogel-based 3D bioprinting: A comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives. Appl Mater Today. 2020; 18. PMC: 7414424. DOI: 10.1016/j.apmt.2019.100479. View

5.
Fan C, Xu K, Huang Y, Liu S, Wang T, Wang W . Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection. Bioact Mater. 2020; 6(4):1150-1162. PMC: 7588753. DOI: 10.1016/j.bioactmat.2020.09.028. View