Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2023 Feb 24

PMID 36825704

Authors

Pooja Mittal

Rajat Goyal

Ramit Kapoor

Chunpeng Wan

Rupesh K Gautam

Affiliations

Soon will be listed here.

Abstract

Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson's disease, Alzheimer's disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement has been found in the treatment of the same. Moreover, it was proved that natural products can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of neuroprotective agents. This review will target the therapeutic potential of various phytochemicals which shows neuroprotective action.

References

Zhao L, Wang J, Liu R, Li X, Li J, Zhang L . Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model. Molecules. 2013; 18(8):9949-65. PMC: 6270497. DOI: 10.3390/molecules18089949. View

Duan X, Li Y, Xu F, Ding H . Study on the neuroprotective effects of Genistein on Alzheimer's disease. Brain Behav. 2021; 11(5):e02100. PMC: 8119804. DOI: 10.1002/brb3.2100. View

Lopez-Miranda V, Soto-Montenegro M, Vera G, Herradon E, Desco M, Abalo R . [Resveratrol: a neuroprotective polyphenol in the Mediterranean diet]. Rev Neurol. 2012; 54(6):349-56. View

Postu P, Noumedem J, Cioanca O, Hancianu M, Mihasan M, Ciorpac M . Lactuca capensis reverses memory deficits in Aβ1-42-induced an animal model of Alzheimer's disease. J Cell Mol Med. 2017; 22(1):111-122. PMC: 5742732. DOI: 10.1111/jcmm.13299. View

Barbalace M, Malaguti M, Giusti L, Lucacchini A, Hrelia S, Angeloni C . Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases. Int J Mol Sci. 2019; 20(12). PMC: 6628294. DOI: 10.3390/ijms20123061. View

Maher P . Protective effects of fisetin and other berry flavonoids in Parkinson's disease. Food Funct. 2017; 8(9):3033-3042. DOI: 10.1039/c7fo00809k. View

Chen C, Lee H, Chang J, Chen S, Li T, Tsai C . Chinese Herb Astragalus membranaceus Enhances Recovery of Hemorrhagic Stroke: Double-Blind, Placebo-Controlled, Randomized Study. Evid Based Complement Alternat Med. 2012; 2012:708452. PMC: 3310143. DOI: 10.1155/2012/708452. View

Hannan M, Dash R, Haque M, Mohibbullah M, Sohag A, Rahman M . Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Mar Drugs. 2020; 18(7). PMC: 7401253. DOI: 10.3390/md18070347. View

Ali T, Yoon G, Shah S, Lee H, Kim M . Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus. Sci Rep. 2015; 5:11708. PMC: 4484370. DOI: 10.1038/srep11708. View

10.

Singh J, Mittal P, Bonde G, Ajmal G, Mishra B . Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment. Artif Cells Nanomed Biotechnol. 2018; 46(sup3):S546-S555. DOI: 10.1080/21691401.2018.1501379. View

11.

Zhang R, Lu H, Tian S, Yin J, Chen Q, Ma L . Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact. 2010; 184(3):484-91. DOI: 10.1016/j.cbi.2010.01.043. View

12.

Chen J, Liu K, Yang T, Hwang J, Chan Y, Lee I . Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells. Nutr Neurosci. 2012; 15(6):252-6. DOI: 10.1179/1476830512Y.0000000020. View

13.

Vardhan H, Mittal P, Adena S, Upadhyay M, Yadav S, Mishra B . Process optimization and in vivo performance of docetaxel loaded PHBV-TPGS therapeutic vesicles: A synergistic approach. Int J Biol Macromol. 2017; 108:729-743. DOI: 10.1016/j.ijbiomac.2017.10.172. View

14.

Sun X, Wei Y, Xiong Y, Wang X, Xie A, Wang X . Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem. 2012; 287(14):11174-82. PMC: 3322889. DOI: 10.1074/jbc.M111.309070. View

15.

Kuzu M, Kandemir F, Yildirim S, Caglayan C, Kucukler S . Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin. Environ Sci Pollut Res Int. 2020; 28(9):10818-10831. DOI: 10.1007/s11356-020-11327-5. View

16.

Vardhan H, Mittal P, Adena S, Mishra B . Long-circulating polyhydroxybutyrate-co-hydroxyvalerate nanoparticles for tumor targeted docetaxel delivery: Formulation, optimization and in vitro characterization. Eur J Pharm Sci. 2016; 99:85-94. DOI: 10.1016/j.ejps.2016.12.007. View

17.

Rahman M, Bajgai J, Fadriquela A, Sharma S, Trinh T, Akter R . Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules. 2021; 26(17). PMC: 8433718. DOI: 10.3390/molecules26175327. View

18.

Mittal P, Vrdhan H, Ajmal G, Bonde G, Kapoor R, Mishra B . Formulation and Characterization of Genistein-loaded Nanostructured Lipid Carriers: Pharmacokinetic, Biodistribution and In vitro Cytotoxicity Studies. Curr Drug Deliv. 2018; 16(3):215-225. DOI: 10.2174/1567201816666181120170137. View

19.

Butterfield D . Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases. J Alzheimers Dis. 2018; 64(s1):S469-S479. DOI: 10.3233/JAD-179912. View

20.

Yang J, Li J, Lu J, Zhang Y, Zhu Z, Wan H . Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia. J Ethnopharmacol. 2011; 140(1):64-72. DOI: 10.1016/j.jep.2011.12.023. View