Tissue Engineering and Regenerative Medicine Strategies for the Repair of Tympanic Membrane Perforations

Overview

Journal Biomater Biosyst

Specialty Biomedical Engineering

Date 2023 Feb 24

PMID 36824158

Authors

Elizabeth Sainsbury

Ronaldo do Amaral

Alexander W Blayney

Rory McConn Walsh

Fergal J OBrien

Cian OLeary

Affiliations

Soon will be listed here.

Abstract

Despite the high success rate of autologous grafts in tympanic membrane repair, clinical alternatives are required for the closure of unresponsive chronic perforations that can lead to recurring infection and hearing loss. Tissue engineering and regenerative medicine approaches have emerged as another strategy to repair the eardrum, in addition to negating the need for donor tissue harvest and related surgical iatrogenicities. This review highlights the main approaches using biomaterials, growth factors, and cell therapies towards the healing of complex TM perforations. In addition, we discuss the challenges and advances for the development of reliable animal models, which will allow the optimisation and development of novel techniques. Finally, we indicate technologies that are currently used clinically and others that are closer to the market. The advances here discussed on tissue engineering and regenerative medicine strategies applied to the field of TM perforations will allow otologists, surgeons, and researchers to better bring novel technologies to the bedside as well as to develop new ones.

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