Current Insights into the Functional Roles of Ferroptosis in Musculoskeletal Diseases and Therapeutic Implications

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Feb 23

PMID 36819098

Authors

Fan Zhang

Yuanliang Yan

Yuan Cai

Qiuju Liang

Yuanhong Liu

Bi Peng

Zhijie Xu

Wei Liu

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, and studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies.

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