Is Platelet-rich Plasma Better Than Hyaluronic Acid in the Treatment of Knee Osteoarthritis? A Meta-analysis of Randomized Controlled Trials

Overview

Journal Wideochir Inne Tech Maloinwazyjne

Publisher Termedia

Date 2023 Feb 23

PMID 36818516

Authors

Lichun Wang

Lin Wei

HaoGuang Ma

Mengchang Wang

Sanjay Rastogi

Affiliations

Soon will be listed here.

Abstract

Introduction: Due to the complicated surgical procedure of knee arthroplasty and low effectivity of hyaluronic acid (HA) in the treatment of knee osteoarthritis, various studies highly recommend the use of platelet-rich plasma (PRP). However, some studies also reported lower efficacy and limited use of PRP.

Aim: To analyze systematically the different randomized controlled trials (RCTs) comparing the effectiveness of HA vs. PRP for the treatment of knee osteoarthritis.

Material And Methods: A systematic literature review was conducted using Medline and Central databases for RCTs about the comparison of HA vs. PRP for the treatment of knee osteoarthritis. Studies were included as per the PICOS criteria and relevant event data were extracted. Risk of bias was analyzed and a random-effects model was used to calculate the pooled odds ratio and risk ratio using RevMan software.

Results: A total of 14 studies were included in the meta-analysis from year 2000 to 2021 including 613 patients. The current meta-analysis has a low risk of publication bias and we obtained the pooled odds ratio (OR) of 2.55 (95% CI: 1.35-4.84) with a value of 1.01, value of 52.79, I value of 77%, Z value of 2.87 and p-value < 0.00001. The pooled risk ratio was 1.34 (95% CI: 1.09-1.65) with a value of 0.09, value of 73.48, I value of 84%, Z value of 2.80 and p-value < 0.00001.

Conclusions: The current meta-analysis highly recommends the use of PRP for the treatment of knee osteoarthritis.

Citing Articles

A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis.

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PMID: 39738804 DOI: 10.1007/s10067-024-07264-0.

Efficacy and safety of platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: a systematic review and meta-analysis.

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Gupta A, Sharma S, Potty A Biomedicines. 2023; 11(10).

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