Differential Gene Expression Profiling in Alveolar Echinococcosis Identifies Potential Biomarkers Associated With Angiogenesis

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2023 Feb 23

PMID 36817746

Authors

Maiweilidan Yimingjiang

Abudusalamu Aini

Talaiti Tuergan

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Alveolar echinococcosis (AE) is a worldwide zoonosis caused by . Alveolar echinococcosis is a severe chronic parasitic disease that exhibits a tumor-like growth, with the potential for invasion and distant metastasis; however, the molecular mechanism underlying this condition remains unclear.

Methods: Transcriptome analyses were performed to detect differentially expressed genes (DEGs) in samples from patients with AE with invasion and distant metastasis. The results were further verified by immunohistochemistry.

Results: A total of 1796 DEGs were identified, including 1742 upregulated and 54 downregulated DEGs. A subsequent functional analysis showed that the significant DEGs were involved in the angiogenesis process. Immunohistochemical analysis confirmed the reliability of the transcriptomic data.

Conclusions: These results suggest that angiogenesis is a possible mechanism underlying the tumor-like biological behavior observed during infection. Genes related to this process may play important roles in AE invasion and distant metastasis.

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