Actions of Neuropeptide Y on Innervated and Denervated Rat Tail Arteries

Overview

Journal J Physiol

Specialty Physiology

Date 1987 May 1

PMID 3681705

Citations 9

Authors

T O Neild

Affiliations

Soon will be listed here.

Abstract

1. Neuropeptide Y caused a dose-dependent contraction and depolarization of the smooth muscle of the rat tail artery. 2. 30 nM-neuropeptide Y increased the contraction caused by either nerve-released noradrenaline or smooth muscle action potentials. 3. 30 nM-neuropeptide Y did not change the amplitude or rate of rise of the smooth muscle action potential. It did not change the amplitude of small excitatory junction potentials, suggesting that it did not affect neurotransmitter release. 4. 30 nM-neuropeptide Y increased the contraction caused by exogenous noradrenaline, 5-hydroxytryptamine and K in concentrations that gave submaximal contractions. It did not affect the response to higher concentrations that gave maximal or near-maximal contractions.

Citing Articles

Gender-modulated endogenous baseline neuropeptide Y Y1-receptor activation in the hindlimb of Sprague-Dawley rats.

Jackson D, Milne K, Noble E, Shoemaker J J Physiol. 2004; 562(Pt 1):285-94.

PMID: 15513938 PMC: 1665494. DOI: 10.1113/jphysiol.2004.076141.

Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction.

Lew M, Flanders S Br J Pharmacol. 1999; 126(6):1408-18.

PMID: 10217535 PMC: 1565908. DOI: 10.1038/sj.bjp.0702435.

Interactions between neuropeptide Y and the adenylate cyclase pathway in rat mesenteric small arteries: role of membrane potential.

Prieto D, Buus C, Mulvany M, Nilsson H J Physiol. 1997; 502 ( Pt 2):281-92.

PMID: 9263910 PMC: 1159549. DOI: 10.1111/j.1469-7793.1997.281bk.x.

Neuropeptide Y potentiates calcium-channel currents in single vascular smooth muscle cells.

Xiong Z, Bolzon B, Cheung D Pflugers Arch. 1993; 423(5-6):504-10.

PMID: 8351199 DOI: 10.1007/BF00374948.

Potentiation by neuropeptide Y of vasoconstriction in rat resistance arteries.

Andriantsitohaina R, STOCLET J Br J Pharmacol. 1988; 95(2):419-28.

PMID: 2465806 PMC: 1854192. DOI: 10.1111/j.1476-5381.1988.tb11662.x.

References

GINSBORG B . Electrical changes in the membrane in junctional transmission. Biochim Biophys Acta. 1973; 300(3):289-317. DOI: 10.1016/0304-4157(73)90007-5. View

Lundberg J, Fried G, Pernow J . Co-release of neuropeptide Y and catecholamines upon adrenal activation in the cat. Acta Physiol Scand. 1986; 126(2):231-8. DOI: 10.1111/j.1748-1716.1986.tb07810.x. View

Mulvany M, Halpern W . Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977; 41(1):19-26. DOI: 10.1161/01.res.41.1.19. View

Casteels R, Kitamura K, Kuriyama H, Suzuki H . Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol. 1977; 271(1):63-79. PMC: 1353607. DOI: 10.1113/jphysiol.1977.sp011990. View

Hirst G, Neild T . An analysis of excitatory junctional potentials recorded from arterioles. J Physiol. 1978; 280:87-104. PMC: 1282649. DOI: 10.1113/jphysiol.1978.sp012374. View

Abel P, Urquilla P, Goto K, Westfall D, Robinson R, FLEMING W . Chronic reserpine treatment alters sensitivity and membrane potential of the rabbit saphenous artery. J Pharmacol Exp Ther. 1981; 217(2):430-9. View

Cohen M, Fuller R, Wiley K . Evidence for 5-HT2 receptors mediating contraction in vascular smooth muscle. J Pharmacol Exp Ther. 1981; 218(2):421-5. View

Tatemoto K, Carlquist M, Mutt V . Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982; 296(5858):659-60. DOI: 10.1038/296659a0. View

Nakashima A, Angus J, Johnston C . Comparison of angiotensin converting enzyme inhibitors captopril and MK421-diacid in guinea pig atria. Eur J Pharmacol. 1982; 81(3):487-92. DOI: 10.1016/0014-2999(82)90114-5. View

10.

Mulvany M, Nilsson H, Flatman J . Role of membrane potential in the response of rat small mesenteric arteries to exogenous noradrenaline stimulation. J Physiol. 1982; 332:363-73. PMC: 1197403. DOI: 10.1113/jphysiol.1982.sp014418. View

11.

Neild T, Zelcer E . Noradrenergic neuromuscular transmission with special reference to arterial smooth muscle. Prog Neurobiol. 1982; 19(3):141-58. DOI: 10.1016/0301-0082(82)90004-1. View

12.

Lundberg J, Tatemoto K . Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptor blockade. Acta Physiol Scand. 1982; 116(4):393-402. DOI: 10.1111/j.1748-1716.1982.tb07157.x. View

13.

Lundberg J, Stjarne L . Neuropeptide Y (NPY) depresses the secretion of 3H-noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens. Acta Physiol Scand. 1984; 120(3):477-9. DOI: 10.1111/j.1748-1716.1984.tb07410.x. View

14.

Finkel A, Hirst G, van Helden D . Some properties of excitatory junction currents recorded from submucosal arterioles of guinea-pig ileum. J Physiol. 1984; 351:87-98. PMC: 1193106. DOI: 10.1113/jphysiol.1984.sp015234. View

15.

Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Hakanson R, Sundler F . Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regul Pept. 1984; 8(3):225-35. DOI: 10.1016/0167-0115(84)90064-8. View

16.

Edvinsson L, Ekblad E, Hakanson R, Wahlestedt C . Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol. 1984; 83(2):519-25. PMC: 1987132. DOI: 10.1111/j.1476-5381.1984.tb16516.x. View

17.

Edvinsson L, Emson P, McCulloch J, Tatemoto K, Uddman R . Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ. Acta Physiol Scand. 1984; 122(2):155-63. DOI: 10.1111/j.1748-1716.1984.tb07493.x. View

18.

Dahlof C, Dahlof P, Tatemoto K, Lundberg J . Neuropeptide Y (NPY) reduces field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein. Naunyn Schmiedebergs Arch Pharmacol. 1985; 328(3):327-30. DOI: 10.1007/BF00515562. View

19.

Potter E . Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y?. Neurosci Lett. 1985; 54(2-3):117-21. DOI: 10.1016/s0304-3940(85)80065-3. View

20.

Uddman R, Ekblad E, Edvinsson L, Hakanson R, Sundler F . Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig. Regul Pept. 1985; 10(2-3):243-57. DOI: 10.1016/0167-0115(85)90019-9. View