Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2023 Feb 23

PMID 36814525

Authors

Yi Li

Yuang Zhang

Yiqin Tao

Xianpeng Huang

Chao Yu

Haibin Xu

Jiangjie Chen

Kaishun Xia

Kesi Shi

Yongxiang Zhang

Jingkai Wang

Jiawei Shu

Feng Cheng

Shaoke Wang

Chengzhen Liang

Fangcai Li

Xiaopeng Zhou

Qixin Chen

Affiliations

Soon will be listed here.

Abstract

Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called "microenvironments." Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed.

Citing Articles

Glycan Modifications as Regulators of Stem Cell Fate.

Alghazali R, Nugud A, El-Serafi A Biology (Basel). 2024; 13(2).

PMID: 38392295 PMC: 10886185. DOI: 10.3390/biology13020076.

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