Bioresorbable, Wireless, and Battery-free System for Electrotherapy and Impedance Sensing at Wound Sites

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2023 Feb 22

PMID 36812305

Authors

Joseph W Song

Hanjun Ryu

Wubin Bai

Zhaoqian Xie

Abraham Vazquez-Guardado

Khizar Nandoliya

Raudel Avila

Geumbee Lee

Zhen Song

Jihye Kim

Min-Kyu Lee

Yugang Liu

Mirae Kim

Huifeng Wang

Yixin Wu

Hong-Joon Yoon

Sung Soo Kwak

Jaeho Shin

Kyeongha Kwon

Wei Lu

Xuexian Chen

Yonggang Huang

Guillermo A Ameer

John A Rogers

Affiliations

Soon will be listed here.

Abstract

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

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