Cell Cycle Regulators and Bone: Development and Regeneration

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2023 Feb 22

PMID 36810262

Authors

Alisha Shaikh

Austin A Wesner

Mohanad Abuhattab

Raman G Kutty

Priyatha Premnath

Affiliations

Soon will be listed here.

Abstract

Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell processes. Emerging evidence has demonstrated a role for cell cycle regulators in bone healing/development cascade. We demonstrated that deletion of p21, a cell cycle regulator acting at the G1/S transition enhanced bone repair capacity after a burr-hole injury in the proximal tibia of mice. Similarly, another study has shown that inhibition of p27 can increase bone mineral density and bone formation. Here, we provide a concise review of cell cycle regulators that influence cells like osteoblasts, osteoclasts, and chondrocytes, during development and/or healing of bone. It is imperative to understand the regulatory processes that govern cell cycle during bone healing and development as this will pave the way to develop novel therapies to improve bone healing after injury in instances of aged or osteoporotic fractures.

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