Characterization of Peptide O⋯HN Hydrogen Bonds H-detected N/O Solid-state NMR Spectroscopy

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Feb 22

PMID 36804656

Authors

Ivan Hung

Wenping Mao

Eric G Keeler

Robert G Griffin

Peter L Gorkov

Zhehong Gan

Affiliations

Soon will be listed here.

Abstract

High sensitivity and resolution solid-state NMR methods are reported, that straightforwardly select hydrogen-bonded N-O pairs from amongst all other nitrogen and oxygen sites in peptides, to aid protein secondary and tertiary structure determination. Significantly improved sensitivity is obtained with indirect H detection under fast MAS and stronger relayed dipole couplings.

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