Matrix Metalloproteinase-7 and Claudin-7 As Novel Identified Therapeutic Targets for Restoration of Intestinal Epithelial Barrier in Inflammatory Bowel Diseases
Overview
Overview
Journal
Tissue Barriers
Specialties
Anatomy & Histology
Biology
Physiology
Biology
Physiology
Date
2023 Feb 21
PMID
36803163
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Intestinal tight junction disruption and mucosal immune dysregulation contribute to pathogenesis and progression of inflammatory bowel diseases (IBD). A proteolytic enzyme matrix metalloproteinase 7 (MMP-7), which is highly expressed in intestinal tissue, is implicated to IBD and other immune overactivation-associated diseases. In the issue of the Frontiers in Immunology, Ying Xiao and colleagues demonstrate that MMP-7-mediated claudin-7 degradation promotes IBD pathogenesis and disease progression. Therefore, inhibition of MMP-7 enzymatic activity can be a therapeutic strategy for the treatment of IBD.
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