How Longitudinal Data Can Contribute to Our Understanding of Host Genetic Effects on the Gut Microbiome

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2023 Feb 16

PMID 36794811

Authors

Laura Grieneisen

Ran Blekhman

Elizabeth Archie

Affiliations

Soon will be listed here.

Abstract

A key component of microbiome research is understanding the role of host genetic influence on gut microbial composition. However, it can be difficult to link host genetics with gut microbial composition because host genetic similarity and environmental similarity are often correlated. Longitudinal microbiome data can supplement our understanding of the relative role of genetic processes in the microbiome. These data can reveal environmentally contingent host genetic effects, both in terms of controlling for environmental differences and in comparing how genetic effects differ by environment. Here, we explore four research areas where longitudinal data could lend new insights into host genetic effects on the microbiome: microbial heritability, microbial plasticity, microbial stability, and host and microbiome population genetics. We conclude with a discussion of methodological considerations for future studies.

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