Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins

Overview

Journal ACS Appl Mater Interfaces

Publisher American Chemical Society

Specialties Biomedical Engineering
Biotechnology

Date 2023 Feb 14

PMID 36786318

Authors

Aamod V Desai

Simon M Vornholt

Louise L Major

Romy Ettlinger

Christian Jansen

Daniel N Rainer

Richard de Rome

Venus So

Paul S Wheatley

Ailsa K Edward

Caroline G Elliott

Atin Pramanik

Avishek Karmakar

A Robert Armstrong

Christoph Janiak

Terry K Smith

Russell E Morris

Affiliations

Soon will be listed here.

Abstract

Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal-organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH(Zr), and UiO-66-NO(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.

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