Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Evolves from TP53-Mutated Clonal Hematopoiesis

Overview

Journal Blood Cancer Discov

Specialties Hematology
Oncology

Date 2023 Feb 13

PMID 36779909

Authors

Ryunosuke Saiki

Seishi Ogawa

Affiliations

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Abstract

Low-hypodiploid acute lymphoblastic leukemia (LH-ALL) in both children and adults is characterized by biallelic TP53 alterations in virtually all cases. However, in contrast to a common germline origin of the TP53 mutations in pediatric cases, those in adult cases are mostly somatic and are derived from age-related clonal hematopoiesis (ARCH), highlighting the role of TP53-mutant ARCH in the development not only of myeloid leukemogenesis but also of LH-ALL in aged populations. See related article by Kim et al., p. 134 (4).

Citing Articles

variants underlying pediatric low-hypodiploidy B-cell acute lymphoblastic leukemia demonstrate diverse origins and may persist as a hematopoietic clone in remission.

Itov A, Ilyasova K, Soldatkina O, Kazakova A, Kozeev V, Semchenkova A EJHaem. 2024; 5(5):1010-1013.

PMID: 39415918 PMC: 11474416. DOI: 10.1002/jha2.986.

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