In-utero Personal Exposure to PM Impacted by Indoor and Outdoor Sources and Birthweight in the MADRES Cohort

Overview

Journal Environ Adv

Specialty Environmental Health

Date 2023 Feb 13

PMID 36778968

Authors

Karl OSharkey

Yan Xu

Thomas Chavez

Mark Johnson

Jane Cabison

Marisela Rosales

Brendan Grubbs

Claudia M Toledo-Corral

Shohreh F Farzan

Theresa Bastain

Carrie V Breton

Rima Habre

Affiliations

Soon will be listed here.

Abstract

Background: In-utero exposure to outdoor particulate matter with aerodynamic diameter less than 2.5 μm (PM) is linked with low birthweight. However, previous results are mixed, likely due to measurement error introduced by estimating personal exposure from ambient data. This study investigated the effect of total personal PM exposure on birthweight and whether it differed when it was more heavily impacted by sources of indoor vs outdoor origin in the MADRES cohort study.

Methods: Personal PM exposure was measured in 205 pregnant women in the 3rd trimester using 48 h integrated, filter-based sampling. Linear regression was used to test the association between personal PM exposure and birthweight, adjusting for key covariates. Interactions of PM with variables representing indoor sources of PM, home ventilation, or time spent indoors tested whether the effect of total PM on birthweight varied when it was more impacted by sources of indoor vs outdoor origin.

Results: In a sample of largely Hispanic (81%) pregnant women, total personal PM was not significantly associated with birthweight (β = 38.6 per 1SD increase in PM; 95% CI:-21.1, 98.2). This association however, differed by home type (single family home: 156.9 (26.9, 287.0), 2-4 attached units:-16.6 (-111.9, 78.7), 5+ units:-62.6 (-184.9, 59.6), missing: 145.4 (-4.1, 294.9), interaction = 0.028) and by household air conditioner use (none of the time: -27.6 (-101.5, 46.3) vs. some of the time: 139.9 (42.9, 237.0), interaction = 0.008) Additionally, the effect of personal PM on birthweight varied by time spent indoors (none or little of the time: - 45.1 (-208.3, 118.1) vs. most or all of the time: 57.1 (-7.3, 121.6), interaction = 0.255).

Conclusions: While no significant association between total personal PM exposure and birthweight was found, there was evidence that multi-unit housing (vs. single-family homes), candle and/or incense smoke, and greater outdoor source contributions to personal PM were more strongly associated with lower birthweight.

Citing Articles

Spatial and temporal determinants of particulate matter peak exposures during pregnancy and early postpartum.

Liu Y, Yi L, Xu Y, Cabison J, Eckel S, Mason T Environ Adv. 2024; 17.

PMID: 39574825 PMC: 11580741. DOI: 10.1016/j.envadv.2024.100557.

Sources of personal PM exposure during pregnancy in the MADRES cohort.

Xu Y, OSharkey K, Cabison J, Rosales M, Chavez T, Johnson M J Expo Sci Environ Epidemiol. 2024; 34(5):868-877.

PMID: 38326532 PMC: 11446843. DOI: 10.1038/s41370-024-00648-z.

Effects of in-utero personal exposure to PM sources and components on birthweight.

OSharkey K, Xu Y, Cabison J, Rosales M, Yang T, Chavez T Sci Rep. 2023; 13(1):21987.

PMID: 38081912 PMC: 10713978. DOI: 10.1038/s41598-023-48920-w.

Effects of In-Utero Personal Exposure to PM2.5 Sources and Components on Birthweight.

OSharkey K, Xu Y, Cabison J, Rosales M, Yang T, Chavez T Res Sq. 2023; .

PMID: 37333108 PMC: 10274950. DOI: 10.21203/rs.3.rs-3026552/v1.

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