HS-based Fluorescent Imaging for Pathophysiological Processes

Overview

Journal Front Chem

Specialty Chemistry

Date 2023 Feb 13

PMID 36778034

Authors

Tong-Tong Jia

Yuanyuan Zhang

Ji-Ting Hou

Huawei Niu

Shan Wang

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS), as an important endogenous signaling molecule, plays a vital role in many physiological processes. The abnormal behaviors of hydrogen sulfide in organisms may lead to various pathophysiological processes. Monitoring the changes in hydrogen sulfide is helpful for pre-warning and treating these pathophysiological processes. Fluorescence imaging techniques can be used to observe changes in the concentration of analytes in organisms in real-time. Therefore, employing fluorescent probes imaging to investigate the behaviors of hydrogen sulfide in pathophysiological processes is vital. This paper reviews the design strategy and sensing mechanisms of hydrogen sulfide-based fluorescent probes, focusing on imaging applications in various pathophysiological processes, including neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes. This review not only demonstrates the specific value of hydrogen sulfide fluorescent probes in preclinical studies but also illuminates the potential application in clinical diagnostics.

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