Perfluorooctanoic Acid (PFOA) Exposure in Relation to the Kidneys: A Review of Current Available Literature

Overview

Journal Front Physiol

Date 2023 Feb 13

PMID 36776978

Authors

Dongge Liu

Shuqi Yan

Pingwei Wang

Qianqian Chen

Yanping Liu

Jiajing Cui

Yujun Liang

Shuping Ren

Ying Gao

Affiliations

Soon will be listed here.

Abstract

Perfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in the human body, there are increasing concerns about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of Perfluorooctanoic acid, and Perfluorooctanoic acid can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarize the relationship between Perfluorooctanoic acid exposure and kidney health, evaluate risks more clearly, and provide a theoretical basis for subsequent research.

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