Association Between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus

Overview

Journal Nutrients

Date 2023 Feb 11

PMID 36771345

Authors

Qunyan Xiang

Hui Xu

Junkun Zhan

Shuzhen Lu

Shuang Li

Yanjiao Wang

Yi Wang

Jieyu He

Yuqing Ni

Linsen Li

Yiyang Liu

Youshuo Liu

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D deficiency (VDD) increases the risk for type 2 diabetes mellitus (T2DM), which might be related to insulin resistance (IR). We aimed to explore the association between the triglyceride-glucose (TyG) index, a reliable indicator of IR, and VDD in patients with T2DM.

Methods: There were 1034 participants with T2DM enrolled in the Second Xiangya Hospital of Central South University. The TyG index was calculated as ln (fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2). VDD was defined as 25-hydroxyvitamin D [25(OH)D] level <50 nmol/L.

Results: Correlation analysis showed a negative association between the TyG index and 25(OH)D level. After adjustments for clinical and laboratory parameters, it was revealed that when taking the Q1 quartile of TyG index as a reference, an increasing trend of VDD prevalence was presented in the other three groups divided by TyG index quartiles, where the OR (95% CI) was 1.708 (1.132-2.576) for Q2, 2.041 (1.315-3.169) for Q3, and 2.543 (1.520-4.253) for Q4 (all < 0.05).

Conclusions: Patients with higher TyG index were more likely to have an increased risk of VDD in T2DM population, which may be related to IR.

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