Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Feb 11

PMID 36770786

Authors

Xingran Kou

Xinping Zhang

Ying Cheng

Miao Yu

Qingran Meng

Qinfei Ke

Affiliations

Soon will be listed here.

Abstract

Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.

Citing Articles

Rapid, Highly-Efficient and Selective Removal of Anionic and Cationic Dyes from Wastewater Using Hollow Polyelectrolyte Microcapsules.

Zhao Z, Zhou H, Han X, Han L, Xu Z, Wang P Molecules. 2023; 28(7).

PMID: 37049773 PMC: 10095712. DOI: 10.3390/molecules28073010.

References

Karrar E, Mahdi A, Sheth S, Mohamed Ahmed I, Manzoor M, Wei W . Effect of maltodextrin combination with gum arabic and whey protein isolate on the microencapsulation of gurum seed oil using a spray-drying method. Int J Biol Macromol. 2020; 171:208-216. DOI: 10.1016/j.ijbiomac.2020.12.045. View

Lee Y, Wu J, Yang M, Young P, van den Berg F, Rantanen J . Particle size dependence of polymorphism in spray-dried mannitol. Eur J Pharm Sci. 2011; 44(1-2):41-8. DOI: 10.1016/j.ejps.2011.06.002. View

Sadek C, Tabuteau H, Schuck P, Fallourd Y, Pradeau N, Le Floch-Fouere C . Shape, shell, and vacuole formation during the drying of a single concentrated whey protein droplet. Langmuir. 2013; 29(50):15606-13. DOI: 10.1021/la404108v. View

Ishida M, Uchiyama J, Isaji K, Suzuki Y, Ikematsu Y, Aoki S . A novel approach to a fine particle coating using porous spherical silica as core particles. Drug Dev Ind Pharm. 2013; 40(8):1054-64. DOI: 10.3109/03639045.2013.807277. View

Chew N, Chan H . Use of solid corrugated particles to enhance powder aerosol performance. Pharm Res. 2002; 18(11):1570-7. DOI: 10.1023/a:1013082531394. View