3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2023 Feb 11

PMID 36770074

Authors

Izabella Rajzer

Anna Kurowska

Jana Frankova

Renata Sklenarova

Anna Nikodem

Michal Dziadek

Adam Jablonski

Jaroslaw Janusz

Piotr Szczygiel

Magdalena Ziabka

Affiliations

Soon will be listed here.

Abstract

In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58-61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation.

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