Primary Stereotactic Radiosurgery Provides Favorable Tumor Control for Intraventricular Meningioma: A Retrospective Analysis

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Feb 11

PMID 36769714

Authors

Motoyuki Umekawa

Yuki Shinya

Hirotaka Hasegawa

Atsuto Katano

Nobuhito Saito

Affiliations

Soon will be listed here.

Abstract

The surgical resection of intraventricular meningiomas (IVMs) remains challenging because of their anatomically deep locations and proximity to vital structures, resulting in non-negligible morbidity and mortality rates. Stereotactic radiosurgery (SRS) is a safe and effective treatment option, providing durable tumor control for benign brain tumors, but its outcomes for IVMs have rarely been reported. Therefore, the goal of the present study was to evaluate the SRS outcomes for IVMs at our institution. This retrospective observational study included 11 patients with 12 IVMs with a median follow-up period of 52 months (range, 3-353 months) treated with SRS using the Leksell Gamma Knife. Nine (75%) tumors were located in the trigone of the lateral ventricle, two (17%) in the body of the lateral ventricle, and one (8%) in the third ventricle. Tumor control was achieved in all cases, and seven (55%) decreased in size. Post-SRS perifocal edema was observed in four (37%; three asymptomatic and one symptomatic but transient) patients, all of which were resolved by the last follow-up. SRS appears to provide safe and excellent tumor control for IVMs. A longer follow-up with a larger number of cases is desired for a more solid conclusion.

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References

Bertalanffy A, Roessler K, Koperek O, Gelpi E, Prayer D, Neuner M . Intraventricular meningiomas: a report of 16 cases. Neurosurg Rev. 2005; 29(1):30-5. DOI: 10.1007/s10143-005-0414-5. View

Cabezudo J, Vaquero J, Areitio E, Bravo G . Meningioma of the anterior part of the third ventricle. Acta Neurochir (Wien). 1981; 56(3-4):219-31. DOI: 10.1007/BF01407232. View

Nundkumar N, Guthikonda M, Mittal S . Peritumoral edema following Gamma Knife radiosurgery as the primary treatment for intraventricular meningiomas. J Clin Neurosci. 2013; 20(4):616-8. DOI: 10.1016/j.jocn.2012.03.041. View

Shin M, Kurita H, Sasaki T, Kawamoto S, Tago M, Kawahara N . Analysis of treatment outcome after stereotactic radiosurgery for cavernous sinus meningiomas. J Neurosurg. 2001; 95(3):435-9. DOI: 10.3171/jns.2001.95.3.0435. View

Riemenschneider M, Perry A, Reifenberger G . Histological classification and molecular genetics of meningiomas. Lancet Neurol. 2006; 5(12):1045-54. DOI: 10.1016/S1474-4422(06)70625-1. View

Pereira B, de Almeida A, Paiva W, de Aguiar P, Teixeira M, Marie S . Natural history of intraventricular meningiomas: systematic review. Neurosurg Rev. 2018; 43(2):513-523. DOI: 10.1007/s10143-018-1019-0. View

Karki P, Yonezawa H, Bohara M, Oyoshi T, Hirano H, Moinuddin F . Third ventricular atypical meningioma which recurred with further malignant progression. Brain Tumor Pathol. 2014; 32(1):56-60. DOI: 10.1007/s10014-014-0183-3. View

Kim I, Kondziolka D, Niranjan A, Flickinger J, Lunsford L . Gamma knife radiosurgery for intraventricular meningiomas. Acta Neurochir (Wien). 2009; 151(5):447-52. DOI: 10.1007/s00701-009-0273-x. View

Bhatoe H, Singh P, Dutta V . Intraventricular meningiomas: a clinicopathological study and review. Neurosurg Focus. 2006; 20(3):E9. DOI: 10.3171/foc.2006.20.3.10. View

10.

Liu M, Wei Y, Liu Y, Zhu S, Li X . Intraventricular meninigiomas: a report of 25 cases. Neurosurg Rev. 2005; 29(1):36-40. DOI: 10.1007/s10143-005-0418-1. View

11.

Li Z, Li H, Jiao Y, Ma J, Wang S, Cao Y . Clinical features and long-term outcomes of pediatric intraventricular meningiomas: data from a single neurosurgical center. Neurosurg Rev. 2017; 41(2):525-530. DOI: 10.1007/s10143-017-0884-2. View

12.

Jamshidi A, Beer-Furlan A, Hardesty D, Ditzel Filho L, Prevedello L, Prevedello D . Management of large intraventricular meningiomas with minimally invasive port technique: a three-case series. Neurosurg Rev. 2020; 44(4):2369-2377. DOI: 10.1007/s10143-020-01409-w. View

13.

Daza-Ovalle A, Bin-Alamer O, Flickinger J, Niranjan A, Lunsford L . Outcomes after gamma knife radiosurgery for intraventricular meningiomas. J Neurooncol. 2022; 160(1):23-31. DOI: 10.1007/s11060-022-04091-8. View

14.

Huang R, Bi W, Weller M, Kaley T, Blakeley J, Dunn I . Proposed response assessment and endpoints for meningioma clinical trials: report from the Response Assessment in Neuro-Oncology Working Group. Neuro Oncol. 2018; 21(1):26-36. PMC: 6303427. DOI: 10.1093/neuonc/noy137. View

15.

Sheehan J, Pikis S, Islim A, Chen C, Bunevicius A, Peker S . An international multicenter matched cohort analysis of incidental meningioma progression during active surveillance or after stereotactic radiosurgery: the IMPASSE study. Neuro Oncol. 2021; 24(1):116-124. PMC: 8730768. DOI: 10.1093/neuonc/noab132. View

16.

Wajima D, Iida J, Nishi N . Third ventricular meningioma--case report. Neurol Med Chir (Tokyo). 2011; 51(1):75-8. DOI: 10.2176/nmc.51.75. View

17.

Forde C, King A, Rutherford S, Hammerbeck-Ward C, Lloyd S, Freeman S . Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution. Neuro Oncol. 2020; 23(7):1113-1124. PMC: 8248850. DOI: 10.1093/neuonc/noaa284. View

18.

Milano M, Sharma M, Soltys S, Sahgal A, Usuki K, Saenz J . Radiation-Induced Edema After Single-Fraction or Multifraction Stereotactic Radiosurgery for Meningioma: A Critical Review. Int J Radiat Oncol Biol Phys. 2018; 101(2):344-357. DOI: 10.1016/j.ijrobp.2018.03.026. View

19.

Mindermann T, Heckl S, Mack A . High incidence of transient perifocal edema following upfront radiosurgery for intraventricular meningiomas. Acta Neurochir (Wien). 2020; 162(9):2177-2182. DOI: 10.1007/s00701-020-04281-1. View

20.

Ramos-Fresnedo A, Domingo R, Sanchez-Garavito J, Perez-Vega C, Akinduro O, Jentoft M . The impact of multiple lesions on progression-free survival of meningiomas: a 10-year multicenter experience. J Neurosurg. 2021; 137(1):9-17. DOI: 10.3171/2021.8.JNS211252. View