Analysis of Single Biomacromolecules and Viruses: Is It a Myth or Reality?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Feb 11

PMID 36768195

Authors

Tatyana O Pleshakova

Yuri D Ivanov

Anastasia A Valueva

Victoria V Shumyantseva

Ekaterina V Ilgisonis

Elena A Ponomarenko

Andrey V Lisitsa

Vladimir P Chekhonin

Alexander I Archakov

Affiliations

Soon will be listed here.

Abstract

The beginning of the twenty-first century witnessed novel breakthrough research directions in the life sciences, such as genomics, transcriptomics, translatomics, proteomics, metabolomics, and bioinformatics. A newly developed single-molecule approach addresses the physical and chemical properties and the functional activity of single (individual) biomacromolecules and viral particles. Within the alternative approach, the combination of "single-molecule approaches" is opposed to "omics approaches". This new approach is fundamentally unique in terms of its research object (a single biomacromolecule). Most studies are currently performed using postgenomic technologies that allow the properties of several hundreds of millions or even billions of biomacromolecules to be analyzed. This paper discusses the relevance and theoretical, methodological, and practical issues related to the development potential of a single-molecule approach using methods based on molecular detectors.

Citing Articles

From Proteomics to the Analysis of Single Protein Molecules.

Ponomarenko E, Ivanov Y, Valueva A, Pleshakova T, Zgoda V, Vavilov N Int J Mol Sci. 2024; 25(19.

PMID: 39408640 PMC: 11476356. DOI: 10.3390/ijms251910308.

Mass Spectrometric Identification of BSA Covalently Captured onto a Chip for Atomic Force Microscopy.

Gordeeva A, Valueva A, Ershova M, Rybakova E, Shumov I, Kozlov A Int J Mol Sci. 2023; 24(10).

PMID: 37240343 PMC: 10219506. DOI: 10.3390/ijms24108999.

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