X-ray Diffraction Study of Cholesterol-phosphatidylserine Mixtures

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1987 Nov 21

PMID 3676345

Citations 4

Authors

E J Wachtel

D Bach

Affiliations

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Abstract

Phosphatidylserine-cholesterol mixtures at a molar ratio of 2:1 were investigated by X-ray diffraction. Phase separation of cholesterol independent of temperature was detected, indicating limited solubility of cholesterol in phosphatidylserine bilayers. The second phase present, the mixed phospholipid-cholesterol phase, continued to undergo melting as determined by changes with temperature in both the small angle scattering profile and in the acyl chain packing.

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