Skin-associated Adipocytes in Skin Barrier Immunity: A Mini-review

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Feb 10

PMID 36761769

Authors

Jingyan Guan

Congxiao Wu

Yunfan He

Feng Lu

Affiliations

Soon will be listed here.

Abstract

The skin contributes critically to health its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity. The integrity and effectiveness of skin barrier immunity strongly depends on the close interplay and communication between immune cells and the skin environment. Skin-associated adipocytes have been recognized to play a significant role in modulating skin immune responses and infection by secreting cytokines, adipokines, and antimicrobial peptides. This review summarizes the recent understanding of the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.

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