Nanomaterials for Diabetic Wound Healing: Visualization and Bibliometric Analysis from 2011 to 2021

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Feb 10

PMID 36761188

Authors

Jun Zhang

Hongyan Liu

Tingting Che

Yin Zheng

Xixi Nan

Zhongming Wu

Affiliations

Soon will be listed here.

Abstract

Background: Nanomaterials have recently been shown to have a considerable advantage in promoting wound healing in diabetic patients or animal models. However, no bibliometric analysis has been conducted to evaluate global scientific production. Herein, this study aimed to summarize the current characteristics, explore research trends, and clarify the direction of nanomaterials and diabetic wound healing in the future.

Methods: Relevant publications from 2011 to 2021 were collected from the Web of Science Core Collection on October 3, 2022. VOSviewer, CiteSpace, bibliometrix-R package, Origin 2021, and Microsoft Excel 2019 were used for bibliometric and visualization analyses.

Results: We identified 409 publications relating to nanomaterials and diabetic wound healing. The number of annual productions remarkably increased from 2011 to 2021, with China and Shanghai Jiao Tong University being the most productive. The most prolific authors were Hasan Anwarul. The leading journal was the International Journal of Biological Macromolecules, with 22 publications. The most popular keywords were "nanoparticles," "delivery," "," "electrospinning," "angiogenesis," and "antibacterial." Keyword burst analysis showed "cerium oxide," "matrix metalloproteinase 9," "composite nanofiber," "hif 1 alpha," and "oxide nanoparticle" were emerging research hotspots.

Conclusion: We found there has been a great progress in the application of nanomaterials in diabetic wound healing from 2011 to 2021. Although many researchers and institutions from different countries or regions contributed contributed to publications, it will be helpful or the development of this field if the degree of international cooperation can be enhanced. In the future, nanomaterials with powerful antioxidant and antibacterial qualities and promoting angiogenesis are the research hotspots.

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References

Zhang J, Huang Y, Xu J, Zhao R, Xiong C, Habu J . Global publication trends and research hotspots of curcumin application in tumor: A 20-year bibliometric approach. Front Oncol. 2022; 12:1033683. PMC: 9589263. DOI: 10.3389/fonc.2022.1033683. View

Yang Y, Huang K, Wang M, Wang Q, Chang H, Liang Y . Ubiquitination Flow Repressors: Enhancing Wound Healing of Infectious Diabetic Ulcers through Stabilization of Polyubiquitinated Hypoxia-Inducible Factor-1α by Theranostic Nitric Oxide Nanogenerators. Adv Mater. 2021; 33(45):e2103593. DOI: 10.1002/adma.202103593. View

Choi J, Leong K, Yoo H . In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials. 2007; 29(5):587-96. DOI: 10.1016/j.biomaterials.2007.10.012. View

Xiao J, Zhu Y, Huddleston S, Li P, Xiao B, Farha O . Copper Metal-Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes. ACS Nano. 2018; 12(2):1023-1032. DOI: 10.1021/acsnano.7b01850. View

Gurtner G, Werner S, Barrandon Y, Longaker M . Wound repair and regeneration. Nature. 2008; 453(7193):314-21. DOI: 10.1038/nature07039. View

Lai H, Kuan C, Wu H, Tsai J, Chen T, Hsieh D . Tailored design of electrospun composite nanofibers with staged release of multiple angiogenic growth factors for chronic wound healing. Acta Biomater. 2014; 10(10):4156-66. DOI: 10.1016/j.actbio.2014.05.001. View

Al Wahbi A . Operative versus non-operative treatment in diabetic dry toe gangrene. Diabetes Metab Syndr. 2019; 13(2):959-963. DOI: 10.1016/j.dsx.2018.12.021. View

Li X, Xie X, Lian W, Shi R, Han S, Zhang H . Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med. 2018; 50(4):1-14. PMC: 5938041. DOI: 10.1038/s12276-018-0058-5. View

Everett E, Mathioudakis N . Update on management of diabetic foot ulcers. Ann N Y Acad Sci. 2018; 1411(1):153-165. PMC: 5793889. DOI: 10.1111/nyas.13569. View

10.

Zarei F, Negahdari B, Eatemadi A . Diabetic ulcer regeneration: stem cells, biomaterials, growth factors. Artif Cells Nanomed Biotechnol. 2017; 46(1):26-32. DOI: 10.1080/21691401.2017.1304407. View

11.

Wang C, Wang M, Xu T, Zhang X, Lin C, Gao W . Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration. Theranostics. 2019; 9(1):65-76. PMC: 6332800. DOI: 10.7150/thno.29766. View

12.

Chereddy K, Coco R, Memvanga P, Ucakar B, des Rieux A, Vandermeulen G . Combined effect of PLGA and curcumin on wound healing activity. J Control Release. 2013; 171(2):208-15. DOI: 10.1016/j.jconrel.2013.07.015. View

13.

Zheng Y, Ley S, Hu F . Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2017; 14(2):88-98. DOI: 10.1038/nrendo.2017.151. View

14.

Aitcheson S, Frentiu F, Hurn S, Edwards K, Murray R . Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds. Molecules. 2021; 26(16). PMC: 8398285. DOI: 10.3390/molecules26164917. View

15.

Stager M, Bardill J, Raichart A, Osmond M, Niemiec S, Zgheib C . Photopolymerized Zwitterionic Hydrogels with a Sustained Delivery of Cerium Oxide Nanoparticle-miR146a Conjugate Accelerate Diabetic Wound Healing. ACS Appl Bio Mater. 2022; 5(3):1092-1103. DOI: 10.1021/acsabm.1c01155. View

16.

Liu M, Wang X, Li H, Xia C, Liu Z, Liu J . Magnesium oxide-incorporated electrospun membranes inhibit bacterial infections and promote the healing process of infected wounds. J Mater Chem B. 2021; 9(17):3727-3744. DOI: 10.1039/d1tb00217a. View

17.

Falanga V . Wound healing and its impairment in the diabetic foot. Lancet. 2005; 366(9498):1736-43. DOI: 10.1016/S0140-6736(05)67700-8. View

18.

Li G, Ko C, Li D, Yang C, Wang W, Yang G . A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nat Commun. 2021; 12(1):3363. PMC: 8184911. DOI: 10.1038/s41467-021-23448-7. View

19.

Wang M, Wang C, Chen M, Xi Y, Cheng W, Mao C . Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release. ACS Nano. 2019; 13(9):10279-10293. DOI: 10.1021/acsnano.9b03656. View

20.

Gourishetti K, Keni R, Nayak P, Jitta S, Bhaskaran N, Kumar L . Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats. Int J Nanomedicine. 2020; 15:9265-9282. PMC: 7695744. DOI: 10.2147/IJN.S268941. View