» Articles » PMID: 36751804

Microglia and Astrocytes Mediate Synapse Engulfment in a MER Tyrosine Kinase-dependent Manner After Traumatic Brain Injury

Overview
Date 2023 Feb 8
PMID 36751804
Authors
Affiliations
Soon will be listed here.
Abstract

Recent studies have shown that microglia/macrophages and astrocytes can mediate synaptic phagocytosis through the MER proto-oncokinase in developmental or stroke models, but it is unclear whether the same mechanism is also active in traumatic brain injury. In this study, we established a mouse model of traumatic brain injury and found that both microglia/macrophages and astrocytes phagocytosed synapses and expression of the MER proto-oncokinase increased 14 days after injury. Specific knockout of MER in microglia/macrophages or astrocytes markedly reduced injury volume and greatly improved neurobehavioral function. In addition, in both microglia/macrophages-specific and astrocytes-specific MER knock-out mice, the number of microglia/macrophage and astrocyte phagocytosing synapses was markedly decreased, and the total number of dendritic spines was increased. Our study suggested that MER proto-oncokinase expression in microglia/macrophages and astrocytes may play an important role in synaptic phagocytosis, and inhibiting this process could be a new strategy for treating traumatic brain injury.

Citing Articles

Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair.

Xu T, Gan L, Chen W, Zheng D, Li H, Deng S Bioact Mater. 2024; 44:558-571.

PMID: 39584066 PMC: 11583666. DOI: 10.1016/j.bioactmat.2024.10.031.


Study on Static Biomechanical Model of Whole Body Based on Virtual Human.

Cheng Z, Luo B, Chen C, Guo H, Wu J, Chen D Sensors (Basel). 2024; 24(20).

PMID: 39459986 PMC: 11511185. DOI: 10.3390/s24206504.


Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases.

Zhang Y, Wang Z, Xu F, Liu Z, Zhao Y, Yang L Neurochem Res. 2024; 49(12):3187-3207.

PMID: 39292330 DOI: 10.1007/s11064-024-04241-6.


Remaking a connection: molecular players involved in post-injury synapse formation.

Tome D, Almeida R Neural Regen Res. 2024; 20(6):1719-1720.

PMID: 39104110 PMC: 11688557. DOI: 10.4103/NRR.NRR-D-24-00265.


Lipid droplets in the nervous system: involvement in cell metabolic homeostasis.

Zhang Y, Chen Y, Zhuang C, Qi J, Zhao R, Wang J Neural Regen Res. 2024; 20(3):740-750.

PMID: 38886939 PMC: 11433920. DOI: 10.4103/NRR.NRR-D-23-01401.


References
1.
Miyamoto A, Wake H, Ishikawa A, Eto K, Shibata K, Murakoshi H . Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun. 2016; 7:12540. PMC: 5007295. DOI: 10.1038/ncomms12540. View

2.
Mollayeva T, Mollayeva S, Colantonio A . Traumatic brain injury: sex, gender and intersecting vulnerabilities. Nat Rev Neurol. 2018; 14(12):711-722. DOI: 10.1038/s41582-018-0091-y. View

3.
Blennow K, Brody D, Kochanek P, Levin H, McKee A, Ribbers G . Traumatic brain injuries. Nat Rev Dis Primers. 2016; 2:16084. DOI: 10.1038/nrdp.2016.84. View

4.
Ren Z, Iliff J, Yang L, Yang J, Chen X, Chen M . 'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation. J Cereb Blood Flow Metab. 2013; 33(6):834-45. PMC: 3677112. DOI: 10.1038/jcbfm.2013.30. View

5.
Izzy S, Liu Q, Fang Z, Lule S, Wu L, Chung J . Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury. Front Cell Neurosci. 2019; 13:307. PMC: 6694299. DOI: 10.3389/fncel.2019.00307. View