Neurovascular Unit Permeability in Neuroinflammatory Diseases: a Common Pathologic and Therapeutic Target?

Overview

Journal Neural Regen Res

Date 2023 Feb 8

PMID 36751789

Authors

Molly Monsour

Cesar V Borlongan

Affiliations

Soon will be listed here.

Citing Articles

Biomarker Profile in Peripheral Blood Cells Related to Alzheimer's Disease.

Lomi M, Geraci F, Del Seppia C, Dolciotti C, Del Carratore R, Bongioanni P Mol Neurobiol. 2025; .

PMID: 40063315 DOI: 10.1007/s12035-025-04767-y.

Endogenous Extracellular Vesicles Participate in Brain Remodeling after Ischemic Stroke.

Muleiro Alvarez M, Esparza Salazar F, Rodriguez T, DEgidio F, Borlongan C, Lee J Int J Mol Sci. 2023; 24(23).

PMID: 38069179 PMC: 10706116. DOI: 10.3390/ijms242316857.

References

Balasa R, Barcutean L, Mosora O, Manu D . Reviewing the Significance of Blood-Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment. Int J Mol Sci. 2021; 22(16). PMC: 8395058. DOI: 10.3390/ijms22168370. View

Ivanidze J, Skafida M, Pandya S, Patel D, Osborne J, Raj A . Molecular Imaging of Striatal Dopaminergic Neuronal Loss and the Neurovascular Unit in Parkinson Disease. Front Neurosci. 2020; 14:528809. PMC: 7530280. DOI: 10.3389/fnins.2020.528809. View

Huang X, Hussain B, Chang J . Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms. CNS Neurosci Ther. 2020; 27(1):36-47. PMC: 7804893. DOI: 10.1111/cns.13569. View

Spitzer D, Guerit S, Puetz T, Khel M, Armbrust M, Dunst M . Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke. Acta Neuropathol. 2022; 144(2):305-337. PMC: 9288377. DOI: 10.1007/s00401-022-02452-1. View

Zhou Y, Chen Q, Wang Y, Wu H, Xu W, Pan Y . Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury. Front Neurosci. 2020; 14:581. PMC: 7296179. DOI: 10.3389/fnins.2020.00581. View

Sarkar S, Raymick J, Mann D, Bowyer J, Hanig J, Schmued L . Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson's disease. Curr Neurovasc Res. 2013; 11(1):48-61. DOI: 10.2174/1567202610666131124234506. View

Anthony S, Cabantan D, Monsour M, Borlongan C . Neuroinflammation, Stem Cells, and Stroke. Stroke. 2022; 53(5):1460-1472. PMC: 9038685. DOI: 10.1161/STROKEAHA.121.036948. View

Monsour M, Garbuzova-Davis S, Borlongan C . Patching Up the Permeability: The Role of Stem Cells in Lessening Neurovascular Damage in Amyotrophic Lateral Sclerosis. Stem Cells Transl Med. 2022; 11(12):1196-1209. PMC: 9801306. DOI: 10.1093/stcltm/szac072. View

Iadecola C . The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Neuron. 2017; 96(1):17-42. PMC: 5657612. DOI: 10.1016/j.neuron.2017.07.030. View

10.

Soto-Rojas L, Pacheco-Herrero M, Martinez-Gomez P, Campa-Cordoba B, Apatiga-Perez R, Villegas-Rojas M . The Neurovascular Unit Dysfunction in Alzheimer's Disease. Int J Mol Sci. 2021; 22(4). PMC: 7922832. DOI: 10.3390/ijms22042022. View

11.

Yu X, Ji C, Shao A . Neurovascular Unit Dysfunction and Neurodegenerative Disorders. Front Neurosci. 2020; 14:334. PMC: 7201055. DOI: 10.3389/fnins.2020.00334. View

12.

Shang S, Zhang H, Feng Y, Wu J, Dou W, Chen Y . Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in Parkinson's Disease. Front Aging Neurosci. 2021; 13:770528. PMC: 8636132. DOI: 10.3389/fnagi.2021.770528. View