Treatment of Chronic Inflammatory Pouch Conditions With Tofacitinib: A Case Series From 2 Tertiary IBD Centers in the United States

Overview

Journal Inflamm Bowel Dis

Publisher Oxford University Press

Specialty Gastroenterology

Date 2023 Feb 6

PMID 36745039

Authors

Shintaro Akiyama

Nathaniel A Cohen

Maia Kayal

Marla C Dubinsky

Jean-Frederic Colombel

David T Rubin

Affiliations

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Are Small Molecules Effective in Treating Inflammatory Pouch Disorders Following Ileal Pouch-Anal Anastomosis for Ulcerative Colitis? Here Is Where We Stand.

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Duodenitis associated with ulcerative colitis and pouchitis after total colectomy successfully treated with upadacitinib: A case report.

Kojima K, Takada J, Otani K, Masuda N, Tezuka Y, Onishi S DEN Open. 2024; 5(1):e415.

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The Natural History After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Population-Based Cohort Study From the United States.

Barnes E, Desai A, Hashash J, Farraye F, Kochhar G Am J Gastroenterol. 2024; 119(11):2267-2274.

PMID: 38888231 PMC: 11534529. DOI: 10.14309/ajg.0000000000002891.

References

Lightner A, Pemberton J, Loftus Jr E . Crohn's Disease of the Ileoanal Pouch. Inflamm Bowel Dis. 2016; 22(6):1502-8. DOI: 10.1097/MIB.0000000000000712. View

Sandborn W, Su C, Sands B, DHaens G, Vermeire S, Schreiber S . Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 2017; 376(18):1723-1736. DOI: 10.1056/NEJMoa1606910. View

Dalal R, Bains K, Marcus J, McClure E, Allegretti J . Tofacitinib for the Treatment of Pouch-Related Disorders: A Case Series. Inflamm Bowel Dis. 2022; 28(11):1787-1789. DOI: 10.1093/ibd/izac147. View

Bauer C, Barnes E, Herfarth H . Tofacitinib in the Treatment of Crohn's-Like Disease of the Pouch. Am J Gastroenterol. 2020; 115(12):2116-2117. DOI: 10.14309/ajg.0000000000000801. View

Schieffer K, Williams E, Yochum G, Koltun W . Review article: the pathogenesis of pouchitis. Aliment Pharmacol Ther. 2016; 44(8):817-35. PMC: 5785099. DOI: 10.1111/apt.13780. View