Association Between Food Intake and Gastrointestinal Symptoms in Patients With Obesity

Overview

Journal Gastro Hep Adv

Specialty Gastroenterology

Date 2023 Feb 6

PMID 36741967

Authors

Wissam Ghusn

Lizeth Cifuentes

Alejandro Campos

Daniel Sacoto

Alan De la Rosa

Fauzi Feris

Gerardo Calderon

Daniel Gonzalez-Izundegui

Jessica Stutzman

Maria Daniela Hurtado

Michael Camilleri

Andres Acosta

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Hunger, satiation, postprandial satiety, and hedonic eating constitute key food intake parameters. We aim to study whether these symptoms are associated with gastrointestinal symptoms (GIS) in patients with obesity.

Methods: This is a cross-sectional study of patients with obesity. Patients completed the following validated biomarkers and questionnaires: hunger was measured via visual analog scale (100 mm) following a standard meal, satiation was measured via meal (calories to fullness; kcal), postprandial satiety was measured via gastric emptying scintigraphy (T; mins), and hedonic eating was measured via the Hospital Anxiety and Depression Scale questionnaire. Participants completed the abridged Bowel Disease Questionnaire to evaluate their GIS. We calculated the odds ratios (ORs) adjusted for sex, weight, and age between food intake parameters <25 or >75 percentile observed in a prior cohort of 450 participants with obesity and GIS.

Results: A total of 274 participants (41 ± 10 [SD] years, 75% females, body mass index 39 ± 8 kg/m) were included in the analysis. Increased hunger was associated with a lower prevalence of lumpy stools (OR = 0.18, = .02). Satiation was associated with abdominal pain/discomfort (relieved by defecation [OR = 2.4, = .02] or associated with change in stool consistency [OR = 2.92, < .01]), loose/watery stools (OR = 2.09, = .02), and bloating (OR = 2.49, < .01). Abnormal postprandial satiety was associated with bloating (OR = 2.26, < .01) and loose/watery stools (OR = 1.84, = .04). Hedonic eating was associated with abdominal pain/discomfort with stool frequency change (OR = 2.4, = .02), >3 bowel movements per day (OR = 1.93, = .048), bloating (OR = 2.49, = .01), abdominal pain after meals >1 per month (OR = 4.24, < .01), and nausea >1 per week (OR = 4.51, < .01).

Conclusion: Alterations in hunger, satiation, postprandial satiety, and hedonic eating are associated with GIS in patients with obesity.

Citing Articles

Precision Medicine in Bariatric Procedures.

Gala K, Ghusn W, Acosta A Gastrointest Endosc Clin N Am. 2024; 34(4):765-779.

PMID: 39277304 PMC: 11403201. DOI: 10.1016/j.giec.2024.03.004.

Mechanism of action and selection of endoscopic bariatric therapies for treatment of obesity.

Ghusn W, Calderon G, Abu Dayyeh B, Acosta A Clin Endosc. 2024; 57(6):701-710.

PMID: 39206501 PMC: 11637673. DOI: 10.5946/ce.2024.005.

Cumulative effect of obesity phenotypes on body weight and body mass index.

Ghusn W, Cifuentes L, Anazco D, Fansa S, Tama E, Campos A Int J Obes (Lond). 2024; 48(6):884-890.

PMID: 38418919 DOI: 10.1038/s41366-024-01492-9.

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