Research Progress of Hydrogels As Delivery Systems and Scaffolds in the Treatment of Secondary Spinal Cord Injury

Overview

Journal Front Bioeng Biotechnol

Date 2023 Feb 6

PMID 36741755

Authors

Haichuan Peng

Yongkang Liu

Fengfeng Xiao

Limei Zhang

Wenting Li

Binghan Wang

Zhijian Weng

Yu Liu

Gang Chen

Affiliations

Soon will be listed here.

Abstract

Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation. Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spinal cord injury. However, the delivery and long-term retention of these additives remain a problem to be solved. In recent years, hydrogels have attracted much attention as a popular delivery system for loading cells and drugs for secondary spinal cord injury therapy. After implantation into the site of spinal cord injury, hydrogels can deliver bioactive additives and induce the unidirectional growth of nerve cells as scaffolds. In addition, physical and chemical methods can endow hydrogels with new functions. In this review, we summarize the current state of various hydrogel delivery systems for secondary spinal cord injury treatment. Moreover, functional modifications of these hydrogels for better therapeutic effects are also discussed to provide a comprehensive insight into the application of hydrogels in the treatment of secondary spinal cord injury.

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