Characteristics Associated with Quality of Life in the Early Stages of Mycosis Fungoides

Overview

Journal Caspian J Intern Med

Specialty General Medicine

Date 2023 Feb 6

PMID 36741488

Authors

Pedram Nourmohammadpour

Maryam Nasimi

Zeinab Aryanian

Azadeh Goodarzi

Reyhaneh Jahazi

Ifa Etesami

Affiliations

Soon will be listed here.

Abstract

Background: Mycosis fungoides (MF) is a lymphoproliferative disorder characterized by skin-homing atypical lymphocytes. This study aimed to evaluate the quality of life (QoL) in MF patients in the early stages of the disease and the associated factors using the Dermatology Life Quality Index (DLQI).

Methods: Thirty MF patients (21 females/9 males) with a mean age of 46.73±15.9 years and in the early stages of the disease (26 stage Ι and 4 stage ΙΙ) were enrolled and were asked to fill the DLQI questionnaire.

Results: The mean DLQI score was 9.93±5.89. The QoL was largely affected by the disease in near half of the patients (46.7% of patients had a DLQI score11-20). QoL was significantly correlated with educational level and was more impaired in patients with lower educational status (DLQI score spearman rho=-0.382, P=0.037). QoL was not associated with sex, age, disease stage and disease duration. The symptom and feeling dimension of DLQI was significantly more impaired in patients with both patch and plaque compared to patch only (spearman rho= 0.397, P= 0.03).

Conclusion: This study demonstrates how largely patients' QoL is influenced in the early stages of MF, especially in patients with lower educational levels.

References

Beynon T, Selman L, Radcliffe E, Whittaker S, Child F, Orlowska D . 'We had to change to single beds because I itch in the night': a qualitative study of the experiences, attitudes and approaches to coping of patients with cutaneous T-cell lymphoma. Br J Dermatol. 2015; 173(1):83-92. DOI: 10.1111/bjd.13732. View

Molloy K, Jonak C, Woei-A-Jin F, Guenova E, Busschots A, Bervoets A . Characteristics associated with significantly worse quality of life in mycosis fungoides/Sézary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study. Br J Dermatol. 2019; 182(3):770-779. DOI: 10.1111/bjd.18089. View

Aghaei S, Sodaifi M, Jafari P, Mazharinia N, Finlay A . DLQI scores in vitiligo: reliability and validity of the Persian version. BMC Dermatol. 2004; 4:8. PMC: 514558. DOI: 10.1186/1471-5945-4-8. View

Segal O, Trumper N, Pavlotsky F, Goldzweig G, Barzilai A . Illness perception, coping, and quality of life in early-stage Mycosis fungoides. An Bras Dermatol. 2020; 96(1):27-33. PMC: 7838113. DOI: 10.1016/j.abd.2020.05.008. View

Finlay A, Khan G . Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994; 19(3):210-6. DOI: 10.1111/j.1365-2230.1994.tb01167.x. View

Wright A, Wijeratne A, Hung T, Gao W, Whittaker S, Morris S . Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma. J Pain Symptom Manage. 2012; 45(1):114-9. DOI: 10.1016/j.jpainsymman.2012.01.012. View

Mohamadi M, Goodarzi A, Aryannejad A, Fattahi N, Alizadeh-Khoei M, Miri S . Geriatric challenges in the new coronavirus disease-19 (COVID-19) pandemic: A systematic review. Med J Islam Repub Iran. 2021; 34:123. PMC: 7787036. DOI: 10.34171/mjiri.34.123. View

Goodarzi A, Mozafarpoor S, Bodaghabadi M, Mohamadi M . The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota. Dermatol Ther. 2020; 33(3):e13279. DOI: 10.1111/dth.13279. View

Najar Nobari N, Seirafianpour F, Mashayekhi F, Goodarzi A . A systematic review on treatment-related mucocutaneous reactions in COVID-19 patients. Dermatol Ther. 2020; 34(1):e14662. PMC: 7883102. DOI: 10.1111/dth.14662. View

10.

Porkert S, Lehner-Baumgartner E, Valencak J, Knobler R, Riedl E, Jonak C . Patients' Illness Perception as a Tool to Improve Individual Disease Management in Primary Cutaneous Lymphomas. Acta Derm Venereol. 2017; 98(2):240-245. DOI: 10.2340/00015555-2819. View

11.

Abedini R, Nasimi M, Noormohammad Pour P, Moghtadaie A, Tohidinik H . Quality of Life in Patients with Non-melanoma Skin Cancer: Implications for Healthcare Education Services and Supports. J Cancer Educ. 2018; 34(4):755-759. DOI: 10.1007/s13187-018-1368-y. View

12.

Graier T, Fink-Puches R, Porkert S, Lang R, Pochlauer S, Ratzinger G . Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it. Front Med (Lausanne). 2020; 7:330. PMC: 7419471. DOI: 10.3389/fmed.2020.00330. View

13.

Herbosa C, Semenov Y, Rosenberg A, Mehta-Shah N, Musiek A . Clinical severity measures and quality-of-life burden in patients with mycosis fungoides and Sézary syndrome: comparison of generic and dermatology-specific instruments. J Eur Acad Dermatol Venereol. 2019; 34(5):995-1003. DOI: 10.1111/jdv.16021. View

14.

Ghodsi S, Chams-Davatchi C, Daneshpazhooh M, Valikhani M, Esmaili N . Quality of life and psychological status of patients with pemphigus vulgaris using Dermatology Life Quality Index and General Health Questionnaires. J Dermatol. 2011; 39(2):141-4. DOI: 10.1111/j.1346-8138.2011.01382.x. View

15.

Ottevanger R, van Beugen S, Evers A, Willemze R, Vermeer M, Quint K . Quality of life in patients with Mycosis Fungoides and Sézary Syndrome: a systematic review of the literature. J Eur Acad Dermatol Venereol. 2021; 35(12):2377-2387. PMC: 9291074. DOI: 10.1111/jdv.17570. View

16.

Olsen E, Vonderheid E, Pimpinelli N, Willemze R, Kim Y, Knobler R . Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment.... Blood. 2007; 110(6):1713-22. DOI: 10.1182/blood-2007-03-055749. View

17.

Semenov Y, Rosenberg A, Herbosa C, Mehta-Shah N, Musiek A . Health-related quality of life and economic implications of cutaneous T-cell lymphoma. Br J Dermatol. 2019; 182(1):190-196. PMC: 7024588. DOI: 10.1111/bjd.17941. View

18.

Maciel P, Veiga-Filho J, Carvalho M, Fonseca F, Ferreira L, Veiga D . Quality of life and self-esteem in patients submitted to surgical treatment of skin carcinomas: long-term results. An Bras Dermatol. 2014; 89(4):594-8. PMC: 4148273. DOI: 10.1590/abd1806-4841.20142742. View

19.

Kim Y, Liu H, Mraz-Gernhard S, Varghese A, Hoppe R . Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression. Arch Dermatol. 2003; 139(7):857-66. DOI: 10.1001/archderm.139.7.857. View

20.

Scarisbrick J, Kim Y, Whittaker S, Wood G, Vermeer M, Prince H . Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?. Br J Dermatol. 2014; 170(6):1226-36. DOI: 10.1111/bjd.12909. View