Prognostic Value of Stem-like Circulating Tumor Cells in Patients with Cancer: a Systematic Review and Meta-analysis

Overview

Journal Clin Exp Med

Specialty General Medicine

Date 2023 Feb 3

PMID 36735207

Authors

Qi Zhang

Defeng Kong

Zhenrong Yang

Guoliang Li

Shujun Cheng

Lin Feng

Kaitai Zhang

Wen Zhang

Affiliations

Soon will be listed here.

Abstract

Despite increasing interest in the study of circulating tumor cells (CTC) subsets, especially epithelial-mesenchymal transition (EMT) and stem cells subsets of CTC that play a key role in tumor recurrence and metastasis, there is no evidence from meta-analyses that shows the correlation between stem-like CTCs and prognosis in cancer patients. Thus, we performed a meta-analysis to assess its prognostic value. Sixteen articles were screened by searching the PubMed, Embase, Cochrane, China National Knowledge Internet (CNKI) and Wanfang databases. The hazard ratio (HR) and 95% confidence interval (95% CI) extracted from each article were summarized. Patients with positive stem-like CTCs in peripheral blood had significantly shorter overall survival (OS, HR: 2.58, 95% CI 1.76-3.79, P < 0.00001), progression-free survival (PFS, HR: 2.21, 95% CI 1.26-3.89, P = 0.006) and disease-free survival (DFS, HR: 2.53, 95% CI: 1.12-5.70, P = 0.03). This study provides the first meta-analysis evidence for the prognostic value of stem-like CTCs, demonstrating that these cells are associated with poor prognosis in cancer patients.Systematic review registrationCRD42022322062.

Citing Articles

Phenotypic Plasticity in Circulating Tumor Cells Is Associated with Poor Response to Therapy in Metastatic Breast Cancer Patients.

Cohen E, Jayachandran G, Gao H, Peabody P, McBride H, Alvarez F Cancers (Basel). 2023; 15(5).

PMID: 36900406 PMC: 10000974. DOI: 10.3390/cancers15051616.

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