» Articles » PMID: 36733921

Responding to Higher-Than-Expected Infant Mortality Rates from Respiratory Syncytial Virus (RSV): Improving Treatment and Reporting Strategies

Overview
Publisher Dove Medical Press
Date 2023 Feb 3
PMID 36733921
Authors
Affiliations
Soon will be listed here.
Abstract

Respiratory syncytial virus (RSV) has a major role in respiratory infections in young infants around the world. However, substantial progress has been made in recent years in the field of RSV. A wide variety of observational studies and clinical trials published in the past decade provide a thorough idea of the health and economic burden of RSV disease in the developing world. In this review, we discuss the impact of RSV burden of disease, major gaps in disease estimations, and challenges in generating new therapeutic options and an immune response against the virus, and briefly describe next generation technologies that are being evaluated.

Citing Articles

Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis.

Dvorkin J, Pecenka C, Sosa E, Sancilio A, Duenas K, Rodriguez A BMJ Public Health. 2025; 2(1):e000975.

PMID: 40018190 PMC: 11812910. DOI: 10.1136/bmjph-2024-000975.


Cost of illness due to respiratory syncytial virus acute lower respiratory tract infection among infants hospitalized in Argentina.

Dvorkin J, Sosa E, Vodicka E, Baral R, Sancilio A, Duenas K BMC Public Health. 2024; 24(1):427.

PMID: 38336643 PMC: 10858556. DOI: 10.1186/s12889-024-17878-3.


The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization.

Wrotek A, Wrotek O, Jackowska T Diseases. 2023; 11(4).

PMID: 37873770 PMC: 10594483. DOI: 10.3390/diseases11040126.

References
1.
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859):2095-128. PMC: 10790329. DOI: 10.1016/S0140-6736(12)61728-0. View

2.
Blanco J, Boukhvalova M, Morrison T, Vogel S . A multifaceted approach to RSV vaccination. Hum Vaccin Immunother. 2018; 14(7):1734-1745. PMC: 6067850. DOI: 10.1080/21645515.2018.1472183. View

3.
Acosta P, Caballero M, Polack F . Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease. Clin Vaccine Immunol. 2015; 23(3):189-95. PMC: 4783420. DOI: 10.1128/CVI.00609-15. View

4.
Shang Z, Tan S, Ma D . Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies. Int J Biol Sci. 2021; 17(14):4073-4091. PMC: 8495404. DOI: 10.7150/ijbs.64762. View

5.
DeVincenzo J, Tait D, Efthimiou J, Mori J, Kim Y, Thomas E . A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2019; 64(2). PMC: 6985722. DOI: 10.1128/AAC.01884-19. View