Role of Gut Microbiome in Atherosclerosis: Molecular and Therapeutic Aspects

Overview

Journal Curr Cardiol Rev

Publisher Bentham Science Publishers

Specialty Cardiology & Vascular Diseases

Date 2023 Feb 3

PMID 36733248

Authors

Juan Salazar

Valery Morillo

Maria K Suarez

Ana Castro

Paola Ramirez

Milagros Rojas

Roberto Anez

Luis DMarco

Maricarmen Chacin-Gonzalez

Valmore Bermudez

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is one of the most relevant and prevalent cardiovascular diseases of our time. It is one of the pathological entities that increases the morbidity and mortality index in the adult population. Pathophysiological connections have been observed between atherosclerosis and the gut microbiome (GM), represented by a group of microorganisms that are present in the gut. These microorganisms are vital for metabolic homeostasis in humans. Recently, direct and indirect mechanisms through which GM can affect the development of atherosclerosis have been studied. This has led to research into the possible modulation of GM and metabolites as a new target in the prevention and treatment of atherosclerosis. The goal of this review is to analyze the physiopathological mechanisms linking GM and atherosclerosis that have been described so far. We also aim to summarize the recent studies that propose GM as a potential target in atherosclerosis management.

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