Antidepressant-like Effect of Endogenous SO on Depression Caused by Chronic Unpredictable Mild Stress

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2023 Feb 2

PMID 36729188

Authors

Mahdieh Salari

Fatemeh Zare Mehrjerdi

Maryam Yadegari

Mohammad Ebrahim Rezvani

Azadeh Shahrokhi Raeini

Affiliations

Soon will be listed here.

Abstract

Sulfur dioxide (SO) is a toxic gas with harmful effects on various organs. However, recent studies have confirmed the protective effect of SO on ischemic heart disease, atherosclerosis, and lung infections. Therefore, the present study was designed to investigate the effect of endogenous SO on depression. The chronic unpredictable mild stress (CUMS) model was performed to cause depression. Depression-like behaviors in animals were determined using an open-field test, forced swimming test, and sucrose consumption. Animal spatial learning and memory were also assessed using the Morris water maze. Besides, the oxidative status of the hippocampus and serum corticosterone level were evaluated. A reduction in the tendency to consume sucrose, mobility, and curiosity, as well as learning and memory disorders were observed in CUMS animals. Depressed animals treated with SO revealed a significant improvement in behavioral and cognitive functions. SO also reduced neuronal damage and lipid peroxidation of the hippocampus and serum corticosterone level in the CUMS group. Various shreds of evidence support a mutual relationship between inflammation and depression; also, growing studies show the role of oxidative stress in the pathogenesis of mood-related disorders such as depression. This study indicated that increased hippocampal malondialdehyde (MDA) and serum corticosterone levels can be due to the existence of oxidative stress and possible activation of inflammatory processes. SO donors diminished MDA and corticosterone levels in depressed animals. According to the study results, SO may be able to reduce tissue damage and eventually behavioral disorders caused by depression by lowering oxidative stress and inflammation.

Citing Articles

Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS).

Nasab M, Rezvani M, Hosseini S, Mehrjerdi F Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(12):10203-10213.

PMID: 39007926 DOI: 10.1007/s00210-024-03284-4.

References

Andersen J . Oxidative stress in neurodegeneration: cause or consequence?. Nat Med. 2004; 10 Suppl:S18-25. DOI: 10.1038/nrn1434. View

Aricioglu F, Ozkartal C, Bastaskin T, Tuzun E, Kandemir C, Sirvanci S . Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats. Clin Psychopharmacol Neurosci. 2019; 17(2):261-272. PMC: 6478084. DOI: 10.9758/cpn.2019.17.2.261. View

Bouayed J, Rammal H, Younos C, Soulimani R . Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice. Eur J Pharmacol. 2007; 564(1-3):146-9. DOI: 10.1016/j.ejphar.2007.02.055. View

Chen S, Zheng S, Liu Z, Tang C, Zhao B, Du J . Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats. Lab Invest. 2015; 95(2):142-56. DOI: 10.1038/labinvest.2014.147. View

Gall Z, Farkas S, Albert A, Ferencz E, Vancea S, Urkon M . Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression. Biomolecules. 2020; 10(5). PMC: 7277553. DOI: 10.3390/biom10050801. View

Gronli J, Bramham C, Murison R, Kanhema T, Fiske E, Bjorvatn B . Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol Biochem Behav. 2007; 85(4):842-9. DOI: 10.1016/j.pbb.2006.11.021. View

Hassan W, Silva C, Mohammadzai I, da Rocha J, J L . Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions. Curr Neuropharmacol. 2014; 12(2):120-39. PMC: 3964744. DOI: 10.2174/1570159X11666131120232135. View

Huang P, Sun Y, Yang J, Chen S, Liu A, Holmberg L . The ERK1/2 signaling pathway is involved in sulfur dioxide preconditioning-induced protection against cardiac dysfunction in isolated perfused rat heart subjected to myocardial ischemia/reperfusion. Int J Mol Sci. 2013; 14(11):22190-201. PMC: 3856059. DOI: 10.3390/ijms141122190. View

Huang Z, Zhong X, Li Z, Feng C, Pan A, Mao Q . Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neurosci Lett. 2011; 493(3):145-8. DOI: 10.1016/j.neulet.2011.02.030. View

10.

Jin H, Liu A, Holmberg L, Zhao M, Chen S, Yang J . The role of sulfur dioxide in the regulation of mitochondrion-related cardiomyocyte apoptosis in rats with isopropylarterenol-induced myocardial injury. Int J Mol Sci. 2013; 14(5):10465-82. PMC: 3676849. DOI: 10.3390/ijms140510465. View

11.

Kendler K, Gardner C . Dependent stressful life events and prior depressive episodes in the prediction of major depression: the problem of causal inference in psychiatric epidemiology. Arch Gen Psychiatry. 2010; 67(11):1120-7. PMC: 3081880. DOI: 10.1001/archgenpsychiatry.2010.136. View

12.

Koprdova R, Bogi E, Belovicova K, Sedlackova N, Okuliarova M, Ujhazy E . Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior. Neuro Endocrinol Lett. 2017; 37(Suppl1):103-110. View

13.

Kumar M, Sandhir R . Hydrogen sulfide attenuates hyperhomocysteinemia-induced mitochondrial dysfunctions in brain. Mitochondrion. 2019; 50:158-169. DOI: 10.1016/j.mito.2019.11.004. View

14.

Li X, Huang L, Wang N, Yi H, Wang H . Sulfur dioxide exposure enhances Th2 inflammatory responses via activating STAT6 pathway in asthmatic mice. Toxicol Lett. 2017; 285:43-50. DOI: 10.1016/j.toxlet.2017.12.020. View

15.

Luo L, Liu D, Tang C, Du J, Liu A, Holmberg L . Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow. Biochem Biophys Res Commun. 2013; 433(4):519-25. DOI: 10.1016/j.bbrc.2013.03.014. View

16.

Rall D . Review of the health effects of sulfur oxides. Environ Health Perspect. 1974; 8:97-121. PMC: 1474939. DOI: 10.1289/ehp.74897. View

17.

Rammal H, Bouayed J, Younos C, Soulimani R . The impact of high anxiety level on the oxidative status of mouse peripheral blood lymphocytes, granulocytes and monocytes. Eur J Pharmacol. 2008; 589(1-3):173-5. DOI: 10.1016/j.ejphar.2008.06.053. View

18.

Sahin E, Gumuslu S . Alterations in brain antioxidant status, protein oxidation and lipid peroxidation in response to different stress models. Behav Brain Res. 2004; 155(2):241-8. DOI: 10.1016/j.bbr.2004.04.022. View

19.

Seki K, Yoshida S, Jaiswal M . Molecular mechanism of noradrenaline during the stress-induced major depressive disorder. Neural Regen Res. 2018; 13(7):1159-1169. PMC: 6065220. DOI: 10.4103/1673-5374.235019. View

20.

Strawbridge R, Arnone D, Danese A, Papadopoulos A, Herane Vives A, Cleare A . Inflammation and clinical response to treatment in depression: A meta-analysis. Eur Neuropsychopharmacol. 2015; 25(10):1532-43. DOI: 10.1016/j.euroneuro.2015.06.007. View