Network-Guided Multiomic Mapping of Aortic Valve Calcification

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2023 Feb 2

PMID 36727519

Authors

Mark C Blaser

Simon Kraler

Thomas F Luscher

Elena Aikawa

Affiliations

Soon will be listed here.

Abstract

Despite devastating clinical sequelae of calcific aortic valve disease that range from left ventricular remodeling to arrhythmias, heart failure, and early death, the molecular insights into disease initiation and progression are limited and pharmacotherapies remain unavailable. The pathobiology of calcific aortic valve disease is complex and comprehensive studies are challenging valvular calcification is heterogeneous and occurs preferentially on the aortic surface, along a fibrocalcific spectrum. Here, we review efforts to study (epi-)genomic, transcriptomic, proteomic, and metabolomic aspects of aortic valve calcification in combination with network medicine-/systems biology-based strategies to integrate multilayered omics datasets and prioritize druggable targets for experimental validation studies. Ultimately, such holistic approach efforts may open therapeutic avenues that go beyond invasive and costly valve replacement therapy.

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